Anti-ADI1 antibody (1-179aa) [AT27E8] (STJA0041648)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenRecombinant human ADI1 (1-179aa) purified from E. coli
General Information
| Short Description | Mouse monoclonal anti-ADI1 (1-179aa) for use in ELISA, WB, ICC and IF in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/WB/ICC/IF |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | AT27E8 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | By protein-A affinity chromatography |
| Formulation | Liquid in phosphate-Buffered Saline (pH 7.4) with 0.02% Sodium Azide, 10% Glycerol |
| Storage Instruction | For short term storage, keep at +2C to +8C for up to 1 week. For long term storage, aliquot and store at-20C, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADI1 |
| Gene ID | 55256 |
| Uniprot ID | MTND_HUMAN |
| Accession Number | NP_060739.1 |
| Immunogen | Recombinant human ADI1 (1-179aa) purified from E. coli |
| Immunogen Region | 1-179aa |
Additional Info
| Tissue Specificity | Detected in heart, colon, lung, stomach, brain, spleen, liver, skeletal muscle and kidney. |
| Function | Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14. Necessary for hepatitis C virus replication in an otherwise non-permissive cell line. |
| Protein Name | Acireductone DioxygenaseAcireductone DioxygenaseFe(2+-RequiringArd'Fe-ArdAcireductone DioxygenaseNi(2+-RequiringArdNi-ArdMembrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1Mtcbp-1Submergence-Induced Protein-Like FactorSip-L |
| Database Links | Reactome: R-HSA-1237112 |
| Cellular Localisation | CytoplasmNucleusCell MembranePeripheral Membrane ProteinCytoplasmic SideLocalizes To The Plasma Membrane When Complexed To Mmp14 |
| Alternative Antibody Names | Anti-Acireductone Dioxygenase antibodyAnti-Acireductone Dioxygenase antibodyAnti-Fe(2+-Requiring antibodyAnti-Ard' antibodyAnti-Fe-Ard antibodyAnti-Acireductone Dioxygenase antibodyAnti-Ni(2+-Requiring antibodyAnti-Ard antibodyAnti-Ni-Ard antibodyAnti-Membrane-Type 1 Matrix Metalloproteinase Cytoplasmic Tail-Binding Protein 1 antibodyAnti-Mtcbp-1 antibodyAnti-Submergence-Induced Protein-Like Factor antibodyAnti-Sip-L antibodyAnti-ADI1 antibodyAnti-MTCBP1 antibodyAnti-HMFT1638 antibody |
Information sourced from Uniprot.org