Anti-ADH5/GSNOR antibody [SRM14538] (STJ11109268)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant protein (or fragment).This information is considered to be commercially sensitive.
General Information
| Short Description | Rabbit monoclonal ADH5/GSNOR antibody for use in WB, IF-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SRM14538 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity purification |
| Dilution Range | WB, 1:5000-1:100000IF-P, 1:100-1:500ELISA, Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADH5 |
| Gene ID | 128 |
| Uniprot ID | ADHX_HUMAN |
| Immunogen | Recombinant protein (or fragment).This information is considered to be commercially sensitive. |
Additional Info
| Function | Catalyzes the oxidation of long-chain primary alcohols and the oxidation of S-(hydroxymethyl) glutathione. Also oxidizes long chain omega-hydroxy fatty acids, such as 20-HETE, producing both the intermediate aldehyde, 20-oxoarachidonate and the end product, a dicarboxylic acid, (5Z,8Z,11Z,14Z)-eicosatetraenedioate. Class-III ADH is remarkably ineffective in oxidizing ethanol. Required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. Also acts as a S-nitroso-glutathione reductase by catalyzing the NADH-dependent reduction of S-nitrosoglutathione, thereby regulating protein S-nitrosylation. |
| Protein Name | Alcohol Dehydrogenase Class-3Alcohol Dehydrogenase 5Alcohol Dehydrogenase Class Chi ChainAlcohol Dehydrogenase Class-IiiGlutathione-Dependent Formaldehyde DehydrogenaseFaldhFdhGsh-FdhS-(Hydroxymethylglutathione Dehydrogenase |
| Database Links | Reactome: R-HSA-71384 |
| Cellular Localisation | Cytoplasm |
| Alternative Antibody Names | Anti-Alcohol Dehydrogenase Class-3 antibodyAnti-Alcohol Dehydrogenase 5 antibodyAnti-Alcohol Dehydrogenase Class Chi Chain antibodyAnti-Alcohol Dehydrogenase Class-Iii antibodyAnti-Glutathione-Dependent Formaldehyde Dehydrogenase antibodyAnti-Faldh antibodyAnti-Fdh antibodyAnti-Gsh-Fdh antibodyAnti-S-(Hydroxymethylglutathione Dehydrogenase antibodyAnti-ADH5 antibodyAnti-ADHX antibodyAnti-FDH antibody |
Information sourced from Uniprot.org