| Post Translational Modifications | Autoproteolysis between residues Leu-226 and Thr-227 occurs in the lumen of the endoplasmic reticulum during receptor biosynthesis. The N-terminal fragment (NTF) subsequently reassociates with the C-terminal fragment (CTF) either in a homogeneric heterodimerization, or with another family member through heterogeneric heterodimerization. Autocatalytic cleavage is thought to be critical for the maturation, stability, trafficking, and function. |
| Function | Adhesion G protein-coupled receptor (GPCR). Transduces intracellular signals through coupling to guanine nucleotide-binding protein G(s) subunit alpha and activation of adenylate cyclase pathway. Isoform 1, but not isoform 2, is constitutively active, as evidenced by elevated basal cAMP levels, and responds to mechanical activation (shaking). |
| Protein Name | Adhesion G-Protein Coupled Receptor G5G-Protein Coupled Receptor 114G-Protein Coupled Receptor Pgr27 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G5 antibodyAnti-G-Protein Coupled Receptor 114 antibodyAnti-G-Protein Coupled Receptor Pgr27 antibodyAnti-ADGRG5 antibodyAnti-GPR114 antibodyAnti-PGR27 antibodyAnti-UNQ2524 antibodyAnti-PRO6017 antibody |
Information sourced from Uniprot.org
