Anti-ADGRG4 antibody (1210-1290 aa) (STJ192651)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 1210-1290
General Information
| Short Description | Rabbit polyclonal anti-Adhesion G-protein coupled receptor G4 (1210-1290 aa) for use in IHC and IF in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/IF |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | IHC-P 1:50-300IF 1:50-200 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADGRG4 |
| Gene ID | 139378 |
| Uniprot ID | AGRG4_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 1210-1290 |
| Immunogen Region | 1210-1290 aa |
| Specificity | GP112 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity. N-glycosylated. |
| Function | Orphan adhesion G-protein coupled receptor (aGPCR). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG4 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. May be act as sensor of mechanical forces. |
| Protein Name | Adhesion G-Protein Coupled Receptor G4G-Protein Coupled Receptor 112 Cleaved Into - Adhesion G-Protein Coupled Receptor G4 - N-Terminal FragmentAdgrg4 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G4 - C-Terminal FragmentAdgrg4 C-Terminal Fragment |
| Database Links | |
| Cellular Localisation | MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor G4 antibodyAnti-G-Protein Coupled Receptor 112 Cleaved Into - Adhesion G-Protein Coupled Receptor G4 - N-Terminal Fragment antibodyAnti-Adgrg4 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G4 - C-Terminal Fragment antibodyAnti-Adgrg4 C-Terminal Fragment antibodyAnti-ADGRG4 antibodyAnti-GPR112 antibody |
Information sourced from Uniprot.org