Anti-ADGRG3 antibody (210-290 aa) (STJ192642)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 210-290
General Information
| Short Description | Rabbit polyclonal anti-Adhesion G protein-coupled receptor G3 (210-290 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADGRG3 |
| Gene ID | 222487 |
| Uniprot ID | AGRG3_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 210-290 |
| Immunogen Region | 210-290 aa |
| Specificity | GPR97 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity. O- and N-glycosylated. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for glucocorticoid hormones such as cortisol, cortisone and 11-deoxycortisol. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRG3/GPR97 is coupled to G(o)/GNAO1 G proteins and mediates signaling by inhibiting adenylate cyclase activity. May also signal through G-alpha(q)-proteins.additional evidence are however required to confirm this result in vivo. Plays a role in the regulation of various processes including B-cell development, inflammation or innate immunity. Regulates migration of lymphatic endothelial cells in vitro via the small GTPases RhoA and CDC42. Antibody ligation leads to the production and activation of antimicrobial mediators like reactive oxygen species (ROS) and myeloperoxidase (MPO) as well as enhanced bacteria uptake and killing by granulocytes. Additionally, collaborates with protease-activated receptor 2/PAR2 to stimulate neutrophil-driven antimicrobial responses and endothelial cell activation. |
| Protein Name | Adhesion G Protein-Coupled Receptor G3G-Protein Coupled Receptor 97 Cleaved Into - Adhesion G-Protein Coupled Receptor G3 - N-Terminal FragmentAdgrg3 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G3 - C-Terminal FragmentAdgrg3 C-Terminal Fragment |
| Database Links | Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor G3 antibodyAnti-G-Protein Coupled Receptor 97 Cleaved Into - Adhesion G-Protein Coupled Receptor G3 - N-Terminal Fragment antibodyAnti-Adgrg3 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor G3 - C-Terminal Fragment antibodyAnti-Adgrg3 C-Terminal Fragment antibodyAnti-ADGRG3 antibodyAnti-GPR97 antibodyAnti-PGR26 antibody |
Information sourced from Uniprot.org