| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-CD97 (240-435) is suitable for use in Western Blot research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:200-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADGRE5 |
| Gene ID: |
976 |
| Uniprot ID: |
AGRE5_HUMAN |
| Immunogen Region: |
240-435 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 240-435 of human CD97 (NP_001775.2). |
| Immunogen Sequence: |
NLEDIMRILAKSLPKGPFTY ISPSNTELTLMIQERGDKNV TMGQSSARMKLNWAVAAGAE DPGPAVAGILSIQNMTTLLA NASLNLHSKKQAELEEIYES SIRGVQLRRLSAVNSIFLSH NNTKELNSPILFAFSHLESS DGEAGRDPPAKDVMPGPRQE LLCAFWKSDSDRGGHWATEG CQVLGSKNGSTTCQCS |
| Tissue Specificity | Broadly expressed, found on most hematopoietic cells, including activated lymphocytes, monocytes, macrophages, dendritic cells, and granulocytes. Expressed also abundantly by smooth muscle cells. Expressed in thyroid, colorectal, gastric, esophageal and pancreatic carcinomas too. Expression are increased under inflammatory conditions in the CNS of multiple sclerosis and in synovial tissue of patients with rheumatoid arthritis. Increased expression of CD97 in the synovium is accompanied by detectable levels of soluble CD97 in the synovial fluid. |
| Post Translational Modifications | Proteolytically cleaved into 2 subunits, an extracellular alpha subunit and a seven-transmembrane subunit. |
| Function | Receptor potentially involved in both adhesion and signaling processes early after leukocyte activation. Plays an essential role in leukocyte migration. |
| Protein Name | Adhesion G Protein-Coupled Receptor E5Leukocyte Antigen Cd97Cd Antigen Cd97 Cleaved Into - Adhesion G Protein-Coupled Receptor E5 Subunit Alpha - Adhesion G Protein-Coupled Receptor E5 Subunit Beta |
| Database Links | Reactome: R-HSA-373080Reactome: R-HSA-6798695 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinAdhesion G Protein-Coupled Receptor E5 Subunit Alpha: SecretedExtracellular Space |
| Alternative Antibody Names | Anti-Adhesion G Protein-Coupled Receptor E5 antibodyAnti-Leukocyte Antigen Cd97 antibodyAnti-Cd Antigen Cd97 Cleaved Into - Adhesion G Protein-Coupled Receptor E5 Subunit Alpha - Adhesion G Protein-Coupled Receptor E5 Subunit Beta antibodyAnti-ADGRE5 antibodyAnti-CD97 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
![Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/300x300/products/93967/375277/STJ114898_1__01767.1713142004.jpg?c=1 "Immunohistochemistry analysis of paraffin-embedded human lung cancer using [KO Validated] NBS1/NBS1/NBN Rabbit polyclonal antibody (STJ114898) at dilution of 1:50 (40x lens). Perform high pressure antigen retrieval with 10 mM citrate buffer pH 6. 0 before commencing with immunohistochemistry staining protocol.")
