Anti-ADGRD1 antibody (461-510 aa) (STJ93334)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenThe antiserum was produced against synthesized peptide derived from the human GPR133 at the amino acid range 461-510
General Information
| Short Description | Rabbit polyclonal anti-Adhesion G-protein coupled receptor D1 (461-510 aa) for use in WB, IF and ELISA in Human and Monkey samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ELISA |
| Host | Rabbit |
| Reactivity | Human/Monkey |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000IF 1:200-1:1000ELISA 1:5000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADGRD1 |
| Gene ID | 283383 |
| Uniprot ID | AGRD1_HUMAN |
| Immunogen | The antiserum was produced against synthesized peptide derived from the human GPR133 at the amino acid range 461-510 |
| Immunogen Region | 461-510 aa |
| Specificity | GPR133 Polyclonal Antibody detects endogenous levels of GPR133 protein. |
Additional Info
| Post Translational Modifications | Autoproteolytically processed at the GPS region of the GAIN-B domain.this cleavage modulates receptor activity . Cleavage takes place early in the secretory pathway before N-glycosylation. |
| Function | Adhesion G-protein coupled receptor (aGPCR) for androgen hormone 5alpha-dihydrotestosterone (5alpha-DHT), also named 17beta-hydroxy-5alpha-androstan-3-one, the most potent hormone among androgens. Also activated by methenolone drug. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of downstream effectors, such as adenylate cyclase. ADGRD1 is coupled to G(s) G proteins and mediates activation of adenylate cyclase activity. Acts as a 5alpha-DHT receptor in muscle cells, thereby increasing intracellular cyclic AMP (cAMP) levels and enhancing muscle strength. |
| Protein Name | Adhesion G-Protein Coupled Receptor D1G-Protein Coupled Receptor 133G-Protein Coupled Receptor Pgr25 Cleaved Into - Adhesion G-Protein Coupled Receptor D1 - N-Terminal FragmentAdgrd1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor D1 - C-Terminal FragmentAdgrd1 C-Terminal Fragment |
| Database Links | |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adhesion G-Protein Coupled Receptor D1 antibodyAnti-G-Protein Coupled Receptor 133 antibodyAnti-G-Protein Coupled Receptor Pgr25 Cleaved Into - Adhesion G-Protein Coupled Receptor D1 - N-Terminal Fragment antibodyAnti-Adgrd1 N-Terminal Fragment - Adhesion G-Protein Coupled Receptor D1 - C-Terminal Fragment antibodyAnti-Adgrd1 C-Terminal Fragment antibodyAnti-ADGRD1 antibodyAnti-GPR133 antibodyAnti-PGR25 antibody |
Information sourced from Uniprot.org