• Western blot with Anti-ADCY6 Antibody (STJ502058) with peptide on at 1:500 dilution in buffer.

Anti-ADCY6 antibody (13-27) (STJ502058)

SKU:
STJ502058-100

£481.50
Shipping:
Free Shipping
Current Stock:
Host: Rabbit
Applications: CM/ELISA/ICC/IF/IHC/IP/WB
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ADCY6 (13-27) is suitable for use in Confocal Microscopy, ELISA, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation and Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Purification: Affinity Purified
Concentration: 0.59 µg/µl
Dilution Range: WB: 1:500
DB: 1:10, 000
ELISA: 1:10, 000
IHC: 1:100-1:200
ICC: 1:100-1:200
IF: 1:100-1:200
CFM: 1:100-1:200
Storage Instruction: Store at-20°C for long term storage. Avoid freeze-thaw cycles.
Gene Symbol: Adcy6
Gene ID: 25289
Uniprot ID: ADCY6_RAT
Immunogen Region: 13-27
Immunogen: Synthetic peptide corresponding to N-terminal amino acids 13-27 of rat Particulate Adenylyl Cyclase 6 protein. Peptide was covalently modified and conjugated to KLH.
Tissue Specificity Detected in brain and kidney. Detected in vascular smooth muscle cells.
Post Translational Modifications Phosphorylation by RAF1 increases enzyme activity. Phosphorylation by PKA on Ser-660 inhibits the GNAS-mediated increase in catalytic activity. Phosphorylation by PKC on Ser-554, Ser-660 and Thr-917 inhibits catalytic activity.
Function Catalyzes the formation of the signaling molecule cAMP downstream of G protein-coupled receptors. Functions in signaling cascades downstream of beta-adrenergic receptors in the heart and in vascular smooth muscle cells. Functions in signaling cascades downstream of the vasopressin receptor in the kidney and has a role in renal water reabsorption. Functions in signaling cascades downstream of PTH1R and plays a role in regulating renal phosphate excretion. Functions in signaling cascades downstream of the VIP and SCT receptors in pancreas and contributes to the regulation of pancreatic amylase and fluid secretion. Signaling mediates cAMP-dependent activation of protein kinase PKA. This promotes increased phosphorylation of various proteins, including AKT. Plays a role in regulating cardiac sarcoplasmic reticulum Ca(2+) uptake and storage, and is required for normal heart ventricular contractibility. May contribute to normal heart function. Mediates vasodilatation after activation of beta-adrenergic receptors by isoproterenol. Contributes to bone cell responses to mechanical stimuli.
Protein Name Adenylate Cyclase Type 6
Atp Pyrophosphate-Lyase 6
Adenylate Cyclase Type Vi
Acvi
Adenylyl Cyclase 6
Ac6
Ca(2+-Inhibitable Adenylyl Cyclase
Database Links Reactome: R-RNO-163615
Reactome: -RNO-170660
Reactome: -RNO-170670
Reactome: -RNO-400042
Reactome: -RNO-418597
Reactome: -RNO-5610787
Cellular Localisation Cell Membrane
Multi-Pass Membrane Protein
Cell Projection
Cilium
Stereocilium
Alternative Antibody Names Anti-Adenylate Cyclase Type 6 antibody
Anti-Atp Pyrophosphate-Lyase 6 antibody
Anti-Adenylate Cyclase Type Vi antibody
Anti-Acvi antibody
Anti-Adenylyl Cyclase 6 antibody
Anti-Ac6 antibody
Anti-Ca(2+-Inhibitable Adenylyl Cyclase antibody
Anti-Adcy6 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance