Anti-ADAMTS8 antibody (176-185) (STJ72187)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ADAMTS8 (176-185) is suitable for use in ELISA research applications. |
| Applications | Pep-ELISA |
| Host | Goat |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:4000.WB: Preliminary experiments in Human Brain (Cerebellum) , Heart, Kidney, Lung, Skeletal Muscle and Placenta lysates gave no specific signal but low background (at antibody concentration up |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAMTS8 |
| Gene ID | 11095 |
| Uniprot ID | ATS8_HUMAN |
| Accession Number | NP_008968.4 |
| Immunogen Region | 176-185 |
| Immunogen Sequence | RQERGDHQED |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Glycosylated. Can be O-fucosylated by POFUT2 on a serine or a threonine residue found within the consensus sequence C1-X(2)-(S/T)-C2-G of the TSP type-1 repeat domains where C1 and C2 are the first and second cysteine residue of the repeat, respectively. Fucosylated repeats can then be further glycosylated by the addition of a beta-1,3-glucose residue by the glucosyltransferase, B3GALTL. Fucosylation mediates the efficient secretion of ADAMTS family members. Can also be C-glycosylated with one or two mannose molecules on tryptophan residues within the consensus sequence W-X-X-W of the TPRs, and N-glycosylated. These other glycosylations can also facilitate secretion. |
| Function | Has anti-angiogenic properties. |
| Protein Name | A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8Adam-Ts 8Adam-Ts8Adamts-8Meth-2Meth-8 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-5083635Reactome: R-HSA-5173214 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-A Disintegrin And Metalloproteinase With Thrombospondin Motifs 8 antibodyAnti-Adam-Ts 8 antibodyAnti-Adam-Ts8 antibodyAnti-Adamts-8 antibodyAnti-Meth-2 antibodyAnti-Meth-8 antibodyAnti-ADAMTS8 antibodyAnti-METH2 antibody |
Information sourced from Uniprot.org