Anti-ADAM9 antibody [DM192] (STJA0038155)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenRecombinant human ADAM9 protein
General Information
| Short Description | Rabbit monoclonal anti-ADAM9 for use in FC and ELISA in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | FC/ELISA |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | DM192 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | FC 1:50-1:100ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide, pH 7.3. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ADAM9 |
| Gene ID | 8754 |
| Uniprot ID | ADAM9_HUMAN |
| Immunogen | Recombinant human ADAM9 protein |
Additional Info
| Tissue Specificity | Widely expressed. Expressed in chondrocytes. Isoform 2 is highly expressed in liver and heart. |
| Post Translational Modifications | Proteolytically cleaved in the trans-Golgi network before it reaches the plasma membrane to generate a mature protein. The removal of the pro-domain occurs via cleavage at two different sites. Processed most likely by a pro-protein convertase such as furin, at the boundary between the pro-domain and the catalytic domain. An additional upstream cleavage pro-protein convertase site (Arg-56/Glu-57) has an important role in the activation of ADAM9. Phosphorylation is induced in vitro by phorbol-12-myristate-13-acetate (PMA). |
| Function | Metalloprotease that cleaves and releases a number of molecules with important roles in tumorigenesis and angiogenesis, such as TEK, KDR, EPHB4, CD40, VCAM1 and CDH5. May mediate cell-cell, cell-matrix interactions and regulate the motility of cells via interactions with integrins. Isoform 2: May act as alpha-secretase for amyloid precursor protein (APP). |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 9Adam 9Cellular Disintegrin-Related ProteinMeltrin-GammaMetalloprotease/Disintegrin/Cysteine-Rich Protein 9Myeloma Cell Metalloproteinase |
| Database Links | Reactome: R-HSA-1442490 |
| Cellular Localisation | Isoform 1: Cell MembraneSingle-Pass Type I Membrane ProteinIsoform 2: Secreted |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 9 antibodyAnti-Adam 9 antibodyAnti-Cellular Disintegrin-Related Protein antibodyAnti-Meltrin-Gamma antibodyAnti-Metalloprotease/Disintegrin/Cysteine-Rich Protein 9 antibodyAnti-Myeloma Cell Metalloproteinase antibodyAnti-ADAM9 antibodyAnti-KIAA0021 antibodyAnti-MCMP antibodyAnti-MDC9 antibodyAnti-MLTNG antibody |
Information sourced from Uniprot.org