Anti-ADAM15 antibody (50-130 aa) (STJ192358)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 50-130
General Information
| Short Description | Rabbit polyclonal anti-Disintegrin and metalloproteinase domain-containing protein 15 (50-130 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAM15 |
| Gene ID | 8751 |
| Uniprot ID | ADA15_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 50-130 |
| Immunogen Region | 50-130 aa |
| Specificity | ADA15 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. Phosphorylation increases association with PTKs. |
| Function | Active metalloproteinase with gelatinolytic and collagenolytic activity. Plays a role in the wound healing process. Mediates both heterotypic intraepithelial cell/T-cell interactions and homotypic T-cell aggregation. Inhibits beta-1 integrin-mediated cell adhesion and migration of airway smooth muscle cells. Suppresses cell motility on or towards fibronectin possibly by driving alpha-v/beta-1 integrin (ITAGV-ITGB1) cell surface expression via ERK1/2 inactivation. Cleaves E-cadherin in response to growth factor deprivation. Plays a role in glomerular cell migration. Plays a role in pathological neovascularization. May play a role in cartilage remodeling. May be proteolytically processed, during sperm epididymal maturation and the acrosome reaction. May play a role in sperm-egg binding through its disintegrin domain. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 15Adam 15Metalloprotease Rgd Disintegrin ProteinMetalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15Mdc-15Metargidin |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-8941237 |
| Cellular Localisation | Endomembrane SystemSingle-Pass Type I Membrane ProteinCell JunctionAdherens JunctionCell ProjectionCiliumFlagellumCytoplasmic VesicleSecretory VesicleAcrosomeThe Majority Of The Protein Is Localized In A Perinuclear Compartment Which May Correspond To The Trans-Golgi Network Or The Late EndosomeThe Pro-Protein Is The Major Detectable Form On The Cell SurfaceWhereas The Majority Of The Protein In The Cell Is Processed |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 15 antibodyAnti-Adam 15 antibodyAnti-Metalloprotease Rgd Disintegrin Protein antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein 15 antibodyAnti-Mdc-15 antibodyAnti-Metargidin antibodyAnti-ADAM15 antibodyAnti-MDC15 antibody |
Information sourced from Uniprot.org