| Host: |
Rabbit |
| Applications: |
WB/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ADAM11 (290-430) is suitable for use in Western Blot and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.01% Thimerosal, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IF/ICC 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ADAM11 |
| Gene ID: |
4185 |
| Uniprot ID: |
ADA11_HUMAN |
| Immunogen Region: |
290-430 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 290-430 of human ADAM11 (NP_002381.2). |
| Immunogen Sequence: |
METWADGDKIQVQDDLLETL ARLMVYRREGLPEPSDATHL FSGRTFQSTSSGAAYVGGIC SLSHGGGVNEYGNMGAMAVT LAQTLGQNLGMMWNKHRSSA GDCKCPDIWLGCIMEDTGFY LPRKFSRCSIDEYNQFLQEG G |
| Tissue Specificity | Expressed predominantly in brain. Slightly detected or not at all in other tissues. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress. Plays a role in spatial learning and motor coordination. Involved in the nociceptive pain response to chemical-derived stimulation. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 11Adam 11Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich ProteinMdc |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonCell ProjectionAxonLocalizes To Basket Cell Terminals And Pinceaux |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 11 antibodyAnti-Adam 11 antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein antibodyAnti-Mdc antibodyAnti-ADAM11 antibodyAnti-MDC antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
