Anti-ADAM11 antibody (290-430) (STJ116462)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ADAM11 (290-430) antibody for use in WB, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IF/ICC:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ADAM11 |
| Gene ID | 4185 |
| Uniprot ID | ADA11_HUMAN |
| Immunogen Region | 290-430 |
| Immunogen Sequence | METWADGDKIQVQDDLLETL ARLMVYRREGLPEPSDATHL FSGRTFQSTSSGAAYVGGIC SLSHGGGVNEYGNMGAMAVT LAQTLGQNLGMMWNKHRSSA GDCKCPDIWLGCIMEDTGFY LPRKFSRCSIDEYNQFLQEG G |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 290-430 of human ADAM11 (NP_002381.2). |
Additional Info
| Tissue Specificity | Expressed predominantly in brain. Slightly detected or not at all in other tissues. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress. Plays a role in spatial learning and motor coordination. Involved in the nociceptive pain response to chemical-derived stimulation. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 11Adam 11Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich ProteinMdc |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonCell ProjectionAxonLocalizes To Basket Cell Terminals And Pinceaux |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 11 antibodyAnti-Adam 11 antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein antibodyAnti-Mdc antibodyAnti-ADAM11 antibodyAnti-MDC antibody |
Information sourced from Uniprot.org