| Tissue Specificity | Expressed predominantly in brain. Slightly detected or not at all in other tissues. |
| Post Translational Modifications | The precursor is cleaved by a furin endopeptidase. |
| Function | Probable ligand for integrin in the brain. This is a non catalytic metalloprotease-like protein. Required for localization of the potassium channel subunit proteins KCNA1/KV1.1 and KCNA2/KV1.2 at cerebellar cortex basket cell distal terminals, is thereby involved in ephaptic inhibitory synchronization of Purkinje cell firing and response to stress. Plays a role in spatial learning and motor coordination. Involved in the nociceptive pain response to chemical-derived stimulation. |
| Protein Name | Disintegrin And Metalloproteinase Domain-Containing Protein 11Adam 11Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich ProteinMdc |
| Database Links | Reactome: R-HSA-5682910 |
| Cellular Localisation | Presynaptic Cell MembraneSingle-Pass Type I Membrane ProteinPerikaryonCell ProjectionAxonLocalizes To Basket Cell Terminals And Pinceaux |
| Alternative Antibody Names | Anti-Disintegrin And Metalloproteinase Domain-Containing Protein 11 antibodyAnti-Adam 11 antibodyAnti-Metalloproteinase-Like - Disintegrin-Like - And Cysteine-Rich Protein antibodyAnti-Mdc antibodyAnti-ADAM11 antibodyAnti-MDC antibody |
Information sourced from Uniprot.org
