Anti-ACVRL1 antibody (234-503) (STJ111113)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ACVRL1 (234-503) antibody for use in WB and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.09% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACVRL1 |
| Gene ID | 94 |
| Uniprot ID | ACVL1_HUMAN |
| Immunogen Region | 234-503 |
| Immunogen Sequence | RDEQSWFRETEIYNTVLLRH DNILGFIASDMTSRNSSTQL WLITHYHEHGSLYDFLQRQT LEPHLALRLAVSAACGLAHL HVEIFGTQGKPAIAHRDFKS RNVLVKSNLQCCIADLGLAV MHSQGSDYLDIGNNPRVGTK RYMAPEVLDEQIRTDCFESY KWTDIWAFGLVLWEIARRTI VNGIVEDYRPPFYDVVPNDP SFEDMKKVVCVDQQTPTIPN RLAADPVLSGLAQMMRECW |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 234-503 of human ACVRL1 (NP_001070869.1). |
Additional Info
| Function | Type I receptor for TGF-beta family ligands BMP9/GDF2 and BMP10 and important regulator of normal blood vessel development. On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. May bind activin as well. |
| Protein Name | Activin Receptor Type-1-LikeActivin Receptor-Like Kinase 1Alk-1Serine/Threonine-Protein Kinase Receptor R3Skr3Tgf-B Superfamily Receptor Type ITsr-I |
| Database Links | Reactome: R-HSA-201451 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Activin Receptor Type-1-Like antibodyAnti-Activin Receptor-Like Kinase 1 antibodyAnti-Alk-1 antibodyAnti-Serine/Threonine-Protein Kinase Receptor R3 antibodyAnti-Skr3 antibodyAnti-Tgf-B Superfamily Receptor Type I antibodyAnti-Tsr-I antibodyAnti-ACVRL1 antibodyAnti-ACVRLK1 antibodyAnti-ALK1 antibody |
Information sourced from Uniprot.org