Host: |
Rabbit |
Applications: |
WB/IHC/IF |
Reactivity: |
Human/Mouse/Rat |
Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Short Description: |
Rabbit polyclonal antibody anti-ACVR2A (20-513) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
Clonality: |
Polyclonal |
Conjugation: |
Unconjugated |
Isotype: |
IgG |
Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
Purification: |
Affinity purification |
Dilution Range: |
WB 1:100-1:500IHC-P 1:100-1:200IF/ICC 1:50-1:200 |
Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Gene Symbol: |
ACVR2A |
Gene ID: |
92 |
Uniprot ID: |
AVR2A_HUMAN |
Immunogen Region: |
20-513 |
Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 20-513 of human ACVR2A (NP_001607.1). |
Immunogen Sequence: |
AILGRSETQECLFFNANWEK DRTNQTGVEPCYGDKDKRRH CFATWKNISGSIEIVKQGCW LDDINCYDRTDCVEKKDSPE VYFCCCEGNMCNEKFSYFPE MEVTQPTSNPVTPKPPYYNI L |
Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. |
Protein Name | Activin Receptor Type-2aActivin Receptor Type IiaActr-IiaActriia |
Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-1502540Reactome: R-HSA-201451 |
Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
Alternative Antibody Names | Anti-Activin Receptor Type-2a antibodyAnti-Activin Receptor Type Iia antibodyAnti-Actr-Iia antibodyAnti-Actriia antibodyAnti-ACVR2A antibodyAnti-ACVR2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance