![Western blot analysis of extracts from wild type (WT) and ACVR2A knockout (KO) 293T cells, using [KO Validated] ACVR2A rabbit monoclonal antibody (STJ11102305) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.](https://cdn11.bigcommerce.com/s-zso2xnchw9/images/stencil/124x110/products/91222/362346/STJ11102305_WB_3__05279.1713127375.jpg?c=1 "Western blot analysis of extracts from wild type (WT) and ACVR2A knockout (KO) 293T cells, using [KO Validated] ACVR2A rabbit monoclonal antibody (STJ11102305) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25ug per lane. Blocking buffer: 3% non-fat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.")
| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human/Mouse/Rat |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Monoclonal |
| Clone ID : | S5MR |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:1000-1:6000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACVR2A |
| Gene ID: | 92 |
| Uniprot ID: | AVR2A_HUMAN |
| Immunogen Region: | 1-100 |
| Specificity: | A synthetic peptide corresponding to a sequence within amino acids 1-100 of human ACVR2A (P27037). |
| Immunogen Sequence: | MGAAAKLAFAVFLISCSSGA ILGRSETQECLFFNANWEKD RTNQTGVEPCYGDKDKRRHC FATWKNISGSIEIVKQGCWL DDINCYDRTDCVEKKDSPEV |
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for activin A, activin B and inhibin A. Mediates induction of adipogenesis by GDF6. |
| Protein Name | Activin Receptor Type-2aActivin Receptor Type IiaActr-IiaActriia |
| Database Links | Reactome: R-HSA-1181150Reactome: R-HSA-1433617Reactome: R-HSA-1502540Reactome: R-HSA-201451Reactome: R-HSA-9839406 |
| Cellular Localisation | Cell MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Activin Receptor Type-2a antibodyAnti-Activin Receptor Type Iia antibodyAnti-Actr-Iia antibodyAnti-Actriia antibodyAnti-ACVR2A antibodyAnti-ACVR2 antibody |
Information sourced from Uniprot.org