• Immunohistochemistry analysis of ACVR1C in paraffin-embedded mouse stomach using ACVR1C Rabbit polyclonal antibody (STJ22505) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of ACVR1C in paraffin-embedded human stomach using ACVR1C Rabbit polyclonal antibody (STJ22505) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Immunohistochemistry analysis of ACVR1C in paraffin-embedded rat brain using ACVR1C Rabbit polyclonal antibody (STJ22505) at dilution of 1:100 (40x lens). Perform microwave antigen retrieval with 10 mM PBS buffer pH 7. 2 before commencing with immunohistochemistry staining protocol.
  • Western blot analysis of various lysates using ACVR1C Rabbit polyclonal antibody (STJ22505) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Enhanced Kit. Exposure time: 180s.
  • Western blot analysis of various lysates using ACVR1C Rabbit polyclonal antibody (STJ22505) at 1:1000 dilution. Secondary antibody: HRP Goat Anti-Rabbit IgG (H+L) (STJS000856) at 1:10000 dilution. Lysates/proteins: 25 Mu g per lane. Blocking buffer: 3% nonfat dry milk in TBST. Detection: ECL Basic Kit. Exposure time: 180s.

Anti-ACVR1C antibody (22-113) (STJ22505)

SKU:
STJ22505

£169.50 - £449.50
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Host: Rabbit
Applications: WB/IHC
Reactivity: Human/Mouse/Rat
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ACVR1C (22-113) is suitable for use in Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: PBS with 0.05% Proclin300, 50% Glycerol, pH7.3.
Purification: Affinity purification
Dilution Range: WB 1:500-1:1000
IHC-P 1:100-1:200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ACVR1C
Gene ID: 130399
Uniprot ID: ACV1C_HUMAN
Immunogen Region: 22-113
Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 22-113 of human ACVR1C (NP_660302.2).
Immunogen Sequence: LSPGLKCVCLLCDSSNFTCQ TEGACWASVMLTNGKEQVIK SCVSLPELNAQVFCHSSNNV TKTECCFTDFCNNITLHLPT ASPNAPKLGPME
Tissue Specificity Present in pancreas, heart, colon, small intestine, ovary and the hippocampus, medulla oblongata and putamen of the brain. Isoform 1, isoform 2, isoform 3 and isoform 4 are all expressed in the placenta throughout pregnancy.
Function Serine/threonine protein kinase which forms a receptor complex on ligand binding. The receptor complex consisting of 2 type II and 2 type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators, SMAD2 and SMAD3. Receptor for activin AB, activin B and NODAL. Plays a role in cell differentiation, growth arrest and apoptosis.
Protein Name Activin Receptor Type-1c
Activin Receptor Type Ic
Actr-Ic
Activin Receptor-Like Kinase 7
Alk-7
Database Links Reactome: R-HSA-1181150
Reactome: R-HSA-1433617
Reactome: R-HSA-1502540
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Activin Receptor Type-1c antibody
Anti-Activin Receptor Type Ic antibody
Anti-Actr-Ic antibody
Anti-Activin Receptor-Like Kinase 7 antibody
Anti-Alk-7 antibody
Anti-ACVR1C antibody
Anti-ALK7 antibody

Information sourced from Uniprot.org

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