• STJ71385 (0. 3µg/ml) staining of Human Umbilical Cord lysate (35µg protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

Anti-ACVR1 antibody (Internal) (STJ71385)

SKU:
STJ71385-100

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Host: Goat
Applications: Pep-ELISA/WB/IHC
Reactivity: Human/Mouse/Rat/Dog
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Goat polyclonal antibody anti-ACVR1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA
Purification: Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
Concentration: 0.5 mg/mL
Dilution Range: WB-0.3-1µg/ml
IHC-Recommended concentration, 4-6µg/ml
ELISA-antibody detection limit dilution 1:128000.
Storage Instruction: Store at-20°C on receipt and minimise freeze-thaw cycles.
Gene Symbol: ACVR1
Gene ID: 90
Uniprot ID: ACVR1_HUMAN
Immunogen Region: Internal
Accession Number: NP_001096.1
Specificity: Reported variants represent identical protein: NP_001096.1, NP_001104537.1
Immunogen Sequence: RKFKRRNQERLNPRD
Function Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. May promote the expression of HAMP, potentially via its interaction with BMP6.
Protein Name Activin Receptor Type-1
Activin Receptor Type I
Actr-I
Activin Receptor-Like Kinase 2
Alk-2
Serine/Threonine-Protein Kinase Receptor R1
Skr1
Tgf-B Superfamily Receptor Type I
Tsr-I
Cellular Localisation Membrane
Single-Pass Type I Membrane Protein
Alternative Antibody Names Anti-Activin Receptor Type-1 antibody
Anti-Activin Receptor Type I antibody
Anti-Actr-I antibody
Anti-Activin Receptor-Like Kinase 2 antibody
Anti-Alk-2 antibody
Anti-Serine/Threonine-Protein Kinase Receptor R1 antibody
Anti-Skr1 antibody
Anti-Tgf-B Superfamily Receptor Type I antibody
Anti-Tsr-I antibody
Anti-ACVR1 antibody
Anti-ACVRLK2 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance