Anti-ACVR1 antibody (Internal) (STJ71385)
SPECIFICATIONS
ClonalityPolyclonal
HostGoat
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Goat polyclonal antibody anti-ACVR1 (Internal) is suitable for use in ELISA, Western Blot and Immunohistochemistry research applications. |
| Applications | Pep-ELISA/WB/IHC |
| Host | Goat |
| Reactivity | Human/Mouse/Rat/Dog |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 0.5 mg/mL |
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Dilution Range | Peptide ELISA: antibody detection limit dilution 1:128000.WB: Approx 60kDa band observed in Human Umbilical Cord lysates (calculated MW of 57.2kDa according to NP_001096.1). Recommended concentration: 0.3-1µg/ml.IHC: In paraffin embedded Hu |
| Formulation | 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin. NA |
| Storage Instruction | Store at-20°C on receipt and minimise freeze-thaw cycles. |
Target Information
| Gene Symbol | ACVR1 |
| Gene ID | 90 |
| Uniprot ID | ACVR1_HUMAN |
| Accession Number | NP_001096.1 |
| Immunogen Region | Internal |
| Immunogen Sequence | RKFKRRNQERLNPRD |
| Specificity | Reported variants represent identical protein: NP_001096.1, NP_001104537.1 |
Additional Info
| Function | Bone morphogenetic protein (BMP) type I receptor that is involved in a wide variety of biological processes, including bone, heart, cartilage, nervous, and reproductive system development and regulation. As a type I receptor, forms heterotetrameric receptor complexes with the type II receptors AMHR2, ACVR2A or ACVR2B. Upon binding of ligands such as BMP7 or GDF2/BMP9 to the heteromeric complexes, type II receptors transphosphorylate ACVR1 intracellular domain. In turn, ACVR1 kinase domain is activated and subsequently phosphorylates SMAD1/5/8 proteins that transduce the signal. In addition to its role in mediating BMP pathway-specific signaling, suppresses TGFbeta/activin pathway signaling by interfering with the binding of activin to its type II receptor. Besides canonical SMAD signaling, can activate non-canonical pathways such as p38 mitogen-activated protein kinases/MAPKs. May promote the expression of HAMP, potentially via its interaction with BMP6. |
| Protein Name | Activin Receptor Type-1Activin Receptor Type IActr-IActivin Receptor-Like Kinase 2Alk-2Serine/Threonine-Protein Kinase Receptor R1Skr1Tgf-B Superfamily Receptor Type ITsr-I |
| Cellular Localisation | MembraneSingle-Pass Type I Membrane Protein |
| Alternative Antibody Names | Anti-Activin Receptor Type-1 antibodyAnti-Activin Receptor Type I antibodyAnti-Actr-I antibodyAnti-Activin Receptor-Like Kinase 2 antibodyAnti-Alk-2 antibodyAnti-Serine/Threonine-Protein Kinase Receptor R1 antibodyAnti-Skr1 antibodyAnti-Tgf-B Superfamily Receptor Type I antibodyAnti-Tsr-I antibodyAnti-ACVR1 antibodyAnti-ACVRLK2 antibody |
Information sourced from Uniprot.org