Anti-ACTR3B antibody (189-418) (STJ110134)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ACTR3B (189-418) antibody for use in WB and ELISA in human and mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACTR3B |
| Gene ID | 57180 |
| Uniprot ID | ARP3B_HUMAN |
| Immunogen Region | 189-418 |
| Immunogen Sequence | CIKHIPIAGRDITYFIQQLL REREVGIPPEQSLETAKAIK EKYCYICPDIVKEFAKYDVD PRKWIKQYTGINAINQKKFV IDVGYERFLGPEIFFHPEFA NPDFMESISDVVDEVIQNCP IDVRRPLYKNVVLSGGSTMF RDFGRRLQRDLKRVVDARLR LSEELSGGRIKPKPVEVQVV THHMQRYAVWFGGSMLASTP EFFQVCHTKKDYEEYGPSIC RHNPVFGVMS |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 189-418 of human ACTR3B (NP_065178.1). |
Additional Info
| Tissue Specificity | Detected in fetal brain. Detected throughout the adult brain, in neurons from gray matter, but not in white matter. Detected in liver, skeletal muscle and pancreas. Detected in lung adenocarcinoma cells with low metastatic potential, but not in lung adenocarcinoma cells with high metastatic potential. |
| Function | Plays a role in the organization of the actin cytoskeleton. May function as ATP-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. May decrease the metastatic potential of tumors. |
| Protein Name | Actin-Related Protein 3bArp3-BetaActin-Like Protein 3bActin-Related Protein Arp4 |
| Database Links | |
| Cellular Localisation | CytoplasmCytoskeletonCell Projection |
| Alternative Antibody Names | Anti-Actin-Related Protein 3b antibodyAnti-Arp3-Beta antibodyAnti-Actin-Like Protein 3b antibodyAnti-Actin-Related Protein Arp4 antibodyAnti-ACTR3B antibodyAnti-ARP11 antibodyAnti-ARP4 antibody |
Information sourced from Uniprot.org