| Host: | Rabbit |
| Applications: | WB, IHC, IF |
| Reactivity: | Human, Mouse, Rat |
| Note: | FOR RESEARCH USE ONLY (RUO). |
| Short Description: | Rabbit polyclonal antibody anti-ACTN2 (1-250) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence. |
| Clonality: | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS containing 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: | Affinity purification |
| Dilution Range: | WB 1:500-1:2000IHC 1:50-1:200IF 1:50-1:200 |
| Storage Instruction: | Store in a freezer at-20°C and avoid freeze-thaw cycles. |
| Gene Symbol: | ACTN2 |
| Gene ID: | 88 |
| Uniprot ID: | ACTN2_HUMAN |
| Immunogen Region: | 1-250 |
| Immunogen: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-250 of human ACTN2 (NP_001094.1). |
| Tissue Specificity | Expressed in both skeletal and cardiac muscle. |
| Post Translational Modifications | Ubiquitinated by FBXL22, leading to proteasomal degradation. |
| Function | F-actin cross-linking protein which is thought to anchor actin to a variety of intracellular structures. This is a bundling protein. |
| Protein Name | Alpha-Actinin-2Alpha-Actinin Skeletal Muscle Isoform 2F-Actin Cross-Linking Protein |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-373753Reactome: R-HSA-390522Reactome: R-HSA-438066Reactome: R-HSA-442982Reactome: R-HSA-5673001Reactome: R-HSA-9609736Reactome: R-HSA-9617324Reactome: R-HSA-9620244 |
| Cellular Localisation | CytoplasmMyofibrilSarcomereZ LineColocalizes With Myoz1 And Flnc At The Z-Lines Of Skeletal Muscle |
| Alternative Antibody Names | Anti-Alpha-Actinin-2 antibodyAnti-Alpha-Actinin Skeletal Muscle Isoform 2 antibodyAnti-F-Actin Cross-Linking Protein antibodyAnti-ACTN2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
