| Host: |
Rabbit |
| Applications: |
WB/IHC/IF |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ACTL6B (1-280) is suitable for use in Western Blot, Immunohistochemistry and Immunofluorescence research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:2000IHC-P 1:50-1:200IF/ICC 1:50-1:100 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACTL6B |
| Gene ID: |
51412 |
| Uniprot ID: |
ACL6B_HUMAN |
| Immunogen Region: |
1-280 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-280 of human ACTL6B (NP_057272.1). |
| Immunogen Sequence: |
MSGGVYGGDEVGALVFDIGS FSVRAGYAGEDCPKADFPTT VGLLAAEEGGGLELEGDKEK KGKIFHIDTNALHVPRDGAE VMSPLKNGMIEDWECFRAIL DHTYSKHVKSEPNLHPVLMS EAPWNTRAKREKLTELMFEQ YNIPAFFLCKTAVLTAFANG RSTGLVLDSGATHTTAIPVH DGYVLQQGIVKSPLAGDFIS MQCRELFQEMAIDIIPPYMI AAKEPVREGAPPNWKKKEK |
| Function | Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Component of SWI/SNF chromatin remodeling complexes that carry out key enzymatic activities, changing chromatin structure by altering DNA-histone contacts within a nucleosome in an ATP-dependent manner. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex), as such plays a role in remodeling mononucleosomes in an ATP-dependent fashion, and is required for postmitotic neural development and dendritic outgrowth. During neural development a switch from a stem/progenitor to a postmitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to postmitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth. ACTL6B/BAF53B is not essential for assembly of the nBAF complex but is required for targeting the complex and CREST to the promoter of genes essential for dendritic growth. Essential for neuronal maturation and dendrite development. |
| Protein Name | Actin-Like Protein 6b53 Kda Brg1-Associated Factor BActin-Related Protein Baf53bArpnalphaBrg1-Associated Factor 53bBaf53b |
| Database Links | Reactome: R-HSA-3214858Reactome: R-HSA-8939243 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Actin-Like Protein 6b antibodyAnti-53 Kda Brg1-Associated Factor B antibodyAnti-Actin-Related Protein Baf53b antibodyAnti-Arpnalpha antibodyAnti-Brg1-Associated Factor 53b antibodyAnti-Baf53b antibodyAnti-ACTL6B antibodyAnti-ACTL6 antibodyAnti-BAF53B antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
