| Host: |
Mouse |
| Applications: |
IHC-P/ELISA/IF |
| Reactivity: |
Human/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Mouse monoclonal antibody anti-ACTH is suitable for use in Immunohistochemistry, ELISA and Immunofluorescence research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
57 |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG1 |
| Formulation: |
PBS with 0.09% sodium azide |
| Concentration: |
1.0mg/mL |
| Storage Instruction: |
Store at 2-8°C upon receipt. |
| Gene Symbol: |
ACTG2 |
| Gene ID: |
72 |
| Uniprot ID: |
ACTH_HUMAN |
| Immunogen: |
Synthetic peptide corresponding to the amino acids 1-24 (SYSMEHFRWGKPVGKKRRPVKVYP) of the human ACTH conjugated to Keyhole Limpet Haemocyanin. |
| Tissue Specificity | In the intestine, abundantly expressed in smooth muscle cells of muscularis mucosa and muscularis propria. Also detected in intestinal vascular smooth muscle cells. |
| Post Translational Modifications | Oxidation of Met-45 and Met-48 by MICALs (MICAL1, MICAL2 or MICAL3) to form methionine sulfoxide promotes actin filament depolymerization. MICAL1 and MICAL2 produce the (R)-S-oxide form. The (R)-S-oxide form is reverted by MSRB1 and MSRB2, which promotes actin repolymerization. Actin, gamma-enteric smooth muscle, intermediate form: N-terminal cleavage of acetylated cysteine of intermediate muscle actin by ACTMAP. Monomethylation at Lys-85 (K84me1) regulates actin-myosin interaction and actomyosin-dependent processes. Demethylation by ALKBH4 is required for maintaining actomyosin dynamics supporting normal cleavage furrow ingression during cytokinesis and cell migration. Methylated at His-74 by SETD3. (Microbial infection) Monomeric actin is cross-linked by V.cholerae toxins RtxA and VgrG1 in case of infection: bacterial toxins mediate the cross-link between Lys-51 of one monomer and Glu-271 of another actin monomer, resulting in formation of highly toxic actin oligomers that cause cell rounding. The toxin can be highly efficient at very low concentrations by acting on formin homology family proteins: toxic actin oligomers bind with high affinity to formins and adversely affect both nucleation and elongation abilities of formins, causing their potent inhibition in both profilin-dependent and independent manners. |
| Function | Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells. |
| Protein Name | Actin - Gamma-Enteric Smooth MuscleAlpha-Actin-3Gamma-2-ActinSmooth Muscle Gamma-Actin Cleaved Into - Actin - Gamma-Enteric Smooth Muscle - Intermediate Form |
| Database Links | Reactome: R-HSA-445355 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Actin - Gamma-Enteric Smooth Muscle antibodyAnti-Alpha-Actin-3 antibodyAnti-Gamma-2-Actin antibodyAnti-Smooth Muscle Gamma-Actin Cleaved Into - Actin - Gamma-Enteric Smooth Muscle - Intermediate Form antibodyAnti-ACTG2 antibodyAnti-ACTA3 antibodyAnti-ACTL3 antibodyAnti-ACTSG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
