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Anti-ACTH antibody [2F6] (STJ16100288)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG1k
ImmunogenA BALB/c mouse was immunized with ACTH synthetic peptide (aa 1-24) conjugated to KLH.Fusion partner: SP2/0.
General Information
| Short Description | Mouse monoclonal anti-ACTH for use in ELISA, FC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA/FC/IF |
| Host | Mouse |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | 2F6 |
| Isotype | IgG1k |
| Conjugation | Unconjugated |
| Concentration | Can be provided as 100 µg/mL, 500 µg/mL or 1mg/mL. |
| Purification | Affinity purified from tissue culture. |
| Dilution Range | ELISA (solid phase: 0, 1-100 µg/ml; tracer: 0, 001-100 µg/ml for 30 min at RT). Flow cytometry (0, 5-1, 0 µg/million cells in 0, 1 ml). Immunofluorescence (0, 5-1, 0 µg/ml. Immunohistology (formalin-fixed: 2-4 µg/ml for 30 min at RT; staining of form |
| Formulation | PBS with 0.02% Sodium Azide. |
| Storage Instruction | Store for up to 1 year at 2-8°C upon receipt. |
Target Information
| Gene Symbol | MC2R |
| Gene ID | 4158 |
| Uniprot ID | ACTHR_HUMAN |
| Immunogen | A BALB/c mouse was immunized with ACTH synthetic peptide (aa 1-24) conjugated to KLH.Fusion partner: SP2/0. |
Additional Info
| Tissue Specificity | Melanocytes and corticoadrenal tissue. |
| Post Translational Modifications | Ubiquitinated by MGRN1 that may be involved in post-endocytic trafficking and/or degradation of internalized receptor. |
| Function | Hormone receptor primarily expressed in adrenal cortex that plays a key role in regulating adrenocortical function. Upon corticotropin (ACTH) binding, facilitates the release of adrenal glucocorticoids, including cortisol and corticosterone. In addition, MC2R is required for fetal and neonatal adrenal gland development. Mechanistically, activates adenylate cyclase (cAMP), the MAPK cascade as well as the cAMP-dependent protein kinase A pathway leading to steroidogenic factor 1/NR5A1-mediated transcriptional activation. |
| Protein Name | Adrenocorticotropic Hormone ReceptorActh ReceptorActh-RAdrenocorticotropin ReceptorMelanocortin Receptor 2Mc2-R |
| Database Links | Reactome: R-HSA-375276Reactome: R-HSA-418555Reactome: R-HSA-5579031 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Adrenocorticotropic Hormone Receptor antibodyAnti-Acth Receptor antibodyAnti-Acth-R antibodyAnti-Adrenocorticotropin Receptor antibodyAnti-Melanocortin Receptor 2 antibodyAnti-Mc2-R antibodyAnti-MC2R antibodyAnti-ACTHR antibody |
Information sourced from Uniprot.org