| Host: | Rabbit |
| Applications: | IF/WB/IHC/ELISA |
| Reactivity: | Human/Mouse/Rat/Chicken/Globefish/Cow/Hamster/Pig/Sheep/Cat/Pig/Dog/Sheep |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal anti-Actin, cytoplasmic 1 (1-80 aa) for use in IF, WB, IHC and ELISA in Human, Mouse, Rat, Chicken, Globefish, Cow, Hamster, Pig, Sheep, Cat, Pig, Dog and Sheep samples. Datasheet included with dilution recommendations, and related |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | IF 1:50-200WB 1:2000-1:10000IHC 1:100-1:300ELISA 1:20000 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACTB |
| Gene ID: | 60 |
| Uniprot ID: | ACTB_HUMAN |
| Immunogen Region: | 1-80 aa |
| Specificity: | Actin Beta Polyclonal Antibody detects endogenous levels of Actin Beta protein. |
| Immunogen: | Synthesized peptide derived from the N-terminal region of human Actin Beta at the amino acid range 1-80 |
| Function | Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm of cells. Actin exists in both monomeric (G-actin) and polymeric (F-actin) forms, both forms playing key functions, such as cell motility and contraction. In addition to their role in the cytoplasmic cytoskeleton, G- and F-actin also localize in the nucleus, and regulate gene transcription and motility and repair of damaged DNA. Plays a role in the assembly of the gamma-tubulin ring complex (gTuRC), which regulates the minus-end nucleation of alpha-beta tubulin heterodimers that grow into microtubule protafilaments. Part of the ACTR1A/ACTB filament around which the dynactin complex is built. The dynactin multiprotein complex activates the molecular motor dynein for ultra-processive transport along microtubules. |
| Protein Name | Actin - Cytoplasmic 1Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed |
| Database Links | Reactome: R-HSA-1445148Reactome: R-HSA-190873Reactome: R-HSA-196025Reactome: R-HSA-2029482Reactome: R-HSA-3214847Reactome: R-HSA-389957Reactome: R-HSA-390450Reactome: R-HSA-3928662Reactome: R-HSA-3928665Reactome: R-HSA-418990Reactome: R-HSA-437239Reactome: R-HSA-4420097Reactome: R-HSA-445095Reactome: R-HSA-446353Reactome: R-HSA-5250924Reactome: R-HSA-5626467Reactome: R-HSA-5663213Reactome: R-HSA-5663220Reactome: R-HSA-5674135Reactome: R-HSA-5689603Reactome: R-HSA-5696394Reactome: R-HSA-6802946Reactome: R-HSA-6802948Reactome: R-HSA-6802952Reactome: R-HSA-6802955Reactome: R-HSA-8856828Reactome: R-HSA-9035034Reactome: R-HSA-9649948Reactome: R-HSA-9656223Reactome: R-HSA-9662360Reactome: R-HSA-9662361Reactome: R-HSA-9664422Reactome: R-HSA-9824585Reactome: R-HSA-983231Reactome: R-HSA-9845323Reactome: R-HSA-9913351 |
| Cellular Localisation | CytoplasmCytoskeletonNucleusLocalized In Cytoplasmic Mrnp Granules Containing Untranslated Mrnas |
| Alternative Antibody Names | Anti-Actin - Cytoplasmic 1 antibodyAnti-Beta-Actin Cleaved Into - Actin - Cytoplasmic 1 - N-Terminally Processed antibodyAnti-ACTB antibody |
Information sourced from Uniprot.org
