| Host: |
Rabbit |
| Applications: |
WB/IHC |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ACOX1 (1-270) is suitable for use in Western Blot and Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:100-1:500IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACOX1 |
| Gene ID: |
51 |
| Uniprot ID: |
ACOX1_HUMAN |
| Immunogen Region: |
1-270 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ACOX1 (NP_004026.2). |
| Immunogen Sequence: |
MNPDLRRERDSASFNPELLT HILDGSPEKTRRRREIENMI LNDPDFQHEDLNFLTRSQRY EVAVRKSAIMVKKMREFGIA DPDEIMWFKNFVHRGRPEPL DLHLGMFLPTLLHQATAEQQ ERFFMPAWNLEIIGTYAQTE MGHGTHLRGLETTATYDPET QEFILNSPTVTSIKWWPGGL GKTSNHAIVLAQLITKGKCY GLHAFIVPIREIGTHKPLPG ITVGDIGPKFGYDEIDNGY |
| Tissue Specificity | Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. |
| Function | Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). Isoform 1: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. Isoform 2: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. |
| Protein Name | Peroxisomal Acyl-Coenzyme A Oxidase 1AoxPalmitoyl-Coa OxidasePeroxisomal Fatty Acyl-Coa OxidaseStraight-Chain Acyl-Coa OxidaseScox Cleaved Into - Peroxisomal Acyl-Coa Oxidase 1 - A Chain - Peroxisomal Acyl-Coa Oxidase 1 - B Chain - Peroxisomal Acyl-Coa Oxidase 1 - C Chain |
| Database Links | Reactome: R-HSA-1989781 Q15067-1Reactome: R-HSA-2046106 Q15067-2Reactome: R-HSA-390247 Q15067-2Reactome: R-HSA-9033241Reactome: R-HSA-9033500 |
| Cellular Localisation | Peroxisome |
| Alternative Antibody Names | Anti-Peroxisomal Acyl-Coenzyme A Oxidase 1 antibodyAnti-Aox antibodyAnti-Palmitoyl-Coa Oxidase antibodyAnti-Peroxisomal Fatty Acyl-Coa Oxidase antibodyAnti-Straight-Chain Acyl-Coa Oxidase antibodyAnti-Scox Cleaved Into - Peroxisomal Acyl-Coa Oxidase 1 - A Chain - Peroxisomal Acyl-Coa Oxidase 1 - B Chain - Peroxisomal Acyl-Coa Oxidase 1 - C Chain antibodyAnti-ACOX1 antibodyAnti-ACOX antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
