Anti-ACOX1 antibody (1-270) (STJ110391)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ACOX1 (1-270) antibody for use in WB, IHC-P and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:1000IHC-P:1:50-1:200ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ACOX1 |
| Gene ID | 51 |
| Uniprot ID | ACOX1_HUMAN |
| Immunogen Region | 1-270 |
| Immunogen Sequence | MNPDLRRERDSASFNPELLT HILDGSPEKTRRRREIENMI LNDPDFQHEDLNFLTRSQRY EVAVRKSAIMVKKMREFGIA DPDEIMWFKNFVHRGRPEPL DLHLGMFLPTLLHQATAEQQ ERFFMPAWNLEIIGTYAQTE MGHGTHLRGLETTATYDPET QEFILNSPTVTSIKWWPGGL GKTSNHAIVLAQLITKGKCY GLHAFIVPIREIGTHKPLPG ITVGDIGPKFGYDEIDNGY |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human ACOX1 (NP_004026.2). |
Additional Info
| Tissue Specificity | Widely expressed with highest levels of isoform 1 and isoform 2 detected in testis. Isoform 1 is expressed at higher levels than isoform 2 in liver and kidney while isoform 2 levels are higher in brain, lung, muscle, white adipose tissue and testis. Levels are almost equal in heart. |
| Function | Involved in the initial and rate-limiting step of peroxisomal beta-oxidation of straight-chain saturated and unsaturated very-long-chain fatty acids. Catalyzes the desaturation of fatty acyl-CoAs such as palmitoyl-CoA (hexadecanoyl-CoA) to 2-trans-enoyl-CoAs ((2E)-enoyl-CoAs) such as (2E)-hexadecenoyl-CoA, and donates electrons directly to molecular oxygen (O(2)), thereby producing hydrogen peroxide (H(2)O(2)). Isoform 1: Shows highest activity against medium-chain fatty acyl-CoAs. Shows optimum activity with a chain length of 10 carbons (decanoyl-CoA) in vitro. Isoform 2: Is active against a much broader range of substrates and shows activity towards long-chain fatty acyl-CoAs. |
| Protein Name | Peroxisomal Acyl-Coenzyme A Oxidase 1AoxPalmitoyl-Coa OxidasePeroxisomal Fatty Acyl-Coa OxidaseStraight-Chain Acyl-Coa OxidaseScox Cleaved Into - Peroxisomal Acyl-Coa Oxidase 1 - A Chain - Peroxisomal Acyl-Coa Oxidase 1 - B Chain - Peroxisomal Acyl-Coa Oxidase 1 - C Chain |
| Database Links | Reactome: R-HSA-1989781 Q15067-1Reactome: R-HSA-2046106 Q15067-2Reactome: R-HSA-390247 Q15067-2Reactome: R-HSA-9033241Reactome: R-HSA-9033500 |
| Cellular Localisation | Peroxisome |
| Alternative Antibody Names | Anti-Peroxisomal Acyl-Coenzyme A Oxidase 1 antibodyAnti-Aox antibodyAnti-Palmitoyl-Coa Oxidase antibodyAnti-Peroxisomal Fatty Acyl-Coa Oxidase antibodyAnti-Straight-Chain Acyl-Coa Oxidase antibodyAnti-Scox Cleaved Into - Peroxisomal Acyl-Coa Oxidase 1 - A Chain - Peroxisomal Acyl-Coa Oxidase 1 - B Chain - Peroxisomal Acyl-Coa Oxidase 1 - C Chain antibodyAnti-ACOX1 antibodyAnti-ACOX antibody |
Information sourced from Uniprot.org