Anti-Acetyl-XPO1-Lys568 antibody (STJ97225)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized acetyl-peptide derived from the Internal region of human CRM1 around the acetylation site of K568.
General Information
| Short Description | Rabbit polyclonal anti-Acetyl-Exportin-1-Lys568 for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-1:2000ELISA 1:10000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | XPO1 |
| Gene ID | 7514 |
| Uniprot ID | XPO1_HUMAN |
| Immunogen | Synthesized acetyl-peptide derived from the Internal region of human CRM1 around the acetylation site of K568. |
| Specificity | Acetyl-CRM1 (K568) Polyclonal Antibody detects endogenous levels of CRM1 protein only when acetylation at K568. |
Additional Info
| Function | Mediates the nuclear export of cellular proteins (cargos) bearing a leucine-rich nuclear export signal (NES) and of RNAs. In the nucleus, in association with RANBP3, binds cooperatively to the NES on its target protein and to the GTPase RAN in its active GTP-bound form (Ran-GTP). Docking of this complex to the nuclear pore complex (NPC) is mediated through binding to nucleoporins. Upon transit of a nuclear export complex into the cytoplasm, disassembling of the complex and hydrolysis of Ran-GTP to Ran-GDP (induced by RANBP1 and RANGAP1, respectively) cause release of the cargo from the export receptor. The directionality of nuclear export is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Involved in U3 snoRNA transport from Cajal bodies to nucleoli. Binds to late precursor U3 snoRNA bearing a TMG cap. (Microbial infection) Mediates the export of unspliced or incompletely spliced RNAs out of the nucleus from different viruses including HIV-1, HTLV-1 and influenza A. Interacts with, and mediates the nuclear export of HIV-1 Rev and HTLV-1 Rex proteins. Involved in HTLV-1 Rex multimerization. |
| Protein Name | Exportin-1Exp1Chromosome Region Maintenance 1 Protein Homolog |
| Database Links | Reactome: R-HSA-141444Reactome: R-HSA-165054Reactome: R-HSA-168333Reactome: R-HSA-2173788Reactome: R-HSA-2467813Reactome: R-HSA-2500257Reactome: R-HSA-3769402Reactome: R-HSA-450520Reactome: R-HSA-5663220Reactome: R-HSA-5687128Reactome: R-HSA-68877Reactome: R-HSA-69273Reactome: R-HSA-9634638Reactome: R-HSA-9648025Reactome: R-HSA-9707616Reactome: R-HSA-9768919Reactome: R-HSA-9828806Reactome: R-HSA-9856649 |
| Cellular Localisation | CytoplasmNucleusNucleoplasmCajal BodyNucleolusLocated In The NucleoplasmCajal Bodies And NucleoliShuttles Between The Nucleus/Nucleolus And The Cytoplasm |
| Alternative Antibody Names | Anti-Exportin-1 antibodyAnti-Exp1 antibodyAnti-Chromosome Region Maintenance 1 Protein Homolog antibodyAnti-XPO1 antibodyAnti-CRM1 antibody |
Information sourced from Uniprot.org