• Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
  • Western blot analysis of lysate from K562 cells, using p73 (Acetyl-Lys321) Antibody.
  • Immunohistochemical analysis of paraffin-embedded human-brain, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-breast, antibody was diluted at 1:100
  • Immunohistochemical analysis of paraffin-embedded human-breast, antibody was diluted at 1:100
  • Western blot analysis of K562 cells using Acetyl-p73 (K321) Polyclonal Antibody. Secondary antibody was diluted at 1:20000
  • Western blot analysis of K562 cells using Acetyl-p73 (K321) Polyclonal Antibody.. Secondary antibody was diluted at 1:20000

Anti-Acetyl-TP73-Lys321 antibody (281-330 aa) (STJ90152)

SKU:
STJ90152

£46.00 - £226.00
Current Stock:
Host: Rabbit
Applications: WB/IHC/IF/ELISA
Reactivity: Human/Rat/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-Acetyl-Tumor protein p73-Lys321 (281-330 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-1:2000
IHC-P 1:100-300
ELISA 1:20000
IF 1:50-200
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: TP73
Gene ID: 7161
Uniprot ID: P73_HUMAN
Immunogen Region: 281-330 aa
Specificity: Acetyl-p73 (K321) Polyclonal Antibody detects endogenous levels of p73 protein only when acetylated at K321.
Immunogen: The antiserum was produced against synthesized Acetyl-peptide derived from the human p73 around the Acetylation site of Lys321 at the amino acid range 281-330
Post Translational Modifications Isoform alpha (but not isoform beta) is sumoylated on Lys-627, which potentiates proteasomal degradation but does not affect transcriptional activity. Phosphorylation by PLK1 and PLK3 inhibits the transcription regulator activity and pro-apoptotic function. Higher levels of phosphorylation seen in the brain from patients with Huntington disease. Polyubiquitinated by RCHY1/PIRH2.leading to its degradation by the proteasome.
Function Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. Is an activator of FOXJ1 expression. It is an essential factor for the positive regulation of lung ciliated cell differentiation.
Protein Name Tumor Protein P73
P53-Like Transcription Factor
P53-Related Protein
Database Links Reactome: R-HSA-139915
Reactome: R-HSA-6803204
Reactome: R-HSA-6803205
Reactome: R-HSA-6803207
Reactome: R-HSA-6803211
Reactome: R-HSA-6804759
Reactome: R-HSA-8939236
Cellular Localisation Nucleus
Cytoplasm
Accumulates In The Nucleus In Response To Dna Damage
Alternative Antibody Names Anti-Tumor Protein P73 antibody
Anti-P53-Like Transcription Factor antibody
Anti-P53-Related Protein antibody
Anti-TP73 antibody
Anti-P73 antibody

Information sourced from Uniprot.org

12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance