| Post Translational Modifications | Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia. Ubiquitinated.subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells. |
| Function | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation. |
| Protein Name | T-Cell Acute Lymphocytic Leukemia Protein 1Tal-1Class A Basic Helix-Loop-Helix Protein 17Bhlha17Stem Cell ProteinT-Cell Leukemia/Lymphoma Protein 5 |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9616222 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-T-Cell Acute Lymphocytic Leukemia Protein 1 antibodyAnti-Tal-1 antibodyAnti-Class A Basic Helix-Loop-Helix Protein 17 antibodyAnti-Bhlha17 antibodyAnti-Stem Cell Protein antibodyAnti-T-Cell Leukemia/Lymphoma Protein 5 antibodyAnti-TAL1 antibodyAnti-BHLHA17 antibodyAnti-SCL antibodyAnti-TCL5 antibody |
Information sourced from Uniprot.org
