Anti-Acetyl-STAT2-Lys384 antibody (STJA0005995)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human Stat2 (Acetyl Lys384)
General Information
| Short Description | Rabbit polyclonal anti-Acetyl-Signal transducer and activator of transcription 2-Lys384 for use in WB, ELISA and IHC in Human and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-p 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | STAT2 |
| Gene ID | 6773 |
| Uniprot ID | STAT2_HUMAN |
| Immunogen | Synthesized peptide derived from human Stat2 (Acetyl Lys384) |
| Specificity | This antibody detects endogenous levels of Human, Rat Stat2 (Acetyl Lys384) |
Additional Info
| Post Translational Modifications | Tyrosine phosphorylated in response to IFN-alpha. Phosphorylation at Ser-287 negatively regulates the transcriptional response. 'Lys-48'-linked ubiquitination by DCST1 leads to STAT2 proteasomal degradation. (Microbial infection) Ubiquitinated by Herpes simplex virus 2 E3 ubiquitin ligase ICP22. |
| Function | Signal transducer and activator of transcription that mediates signaling by type I interferons (IFN-alpha and IFN-beta). Following type I IFN binding to cell surface receptors, Jak kinases (TYK2 and JAK1) are activated, leading to tyrosine phosphorylation of STAT1 and STAT2. The phosphorylated STATs dimerize, associate with IRF9/ISGF3G to form a complex termed ISGF3 transcription factor, that enters the nucleus. ISGF3 binds to the IFN stimulated response element (ISRE) to activate the transcription of interferon stimulated genes, which drive the cell in an antiviral state. In addition, also has a negative feedback regulatory role in the type I interferon signaling by recruiting USP18 to the type I IFN receptor subunit IFNAR2 thereby mitigating the response to type I IFNs. Acts as a regulator of mitochondrial fission by modulating the phosphorylation of DNM1L at 'Ser-616' and 'Ser-637' which activate and inactivate the GTPase activity of DNM1L respectively. |
| Protein Name | Signal Transducer And Activator Of Transcription 2P113 |
| Database Links | Reactome: R-HSA-8854691Reactome: R-HSA-909733Reactome: R-HSA-912694Reactome: R-HSA-9679191Reactome: R-HSA-9705671Reactome: R-HSA-9833109 |
| Cellular Localisation | CytoplasmNucleusTranslocated Into The Nucleus Upon Activation By Ifn-Alpha/Beta |
| Alternative Antibody Names | Anti-Signal Transducer And Activator Of Transcription 2 antibodyAnti-P113 antibodyAnti-STAT2 antibody |
Information sourced from Uniprot.org