Anti-Acetyl-NRIP1-Lys158 antibody (STJ97698)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized acetyl-peptide derived from the human RIP140 around the acetylation site of K158.
General Information
| Short Description | Rabbit polyclonal anti-Acetyl-Nuclear receptor-interacting protein 1-Lys158 for use in WB, ELISA and IHC in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA/IHC |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000IHC-P 1:50-300ELISA 2000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | NRIP1 |
| Gene ID | 8204 |
| Uniprot ID | NRIP1_HUMAN |
| Immunogen | Synthesized acetyl-peptide derived from the human RIP140 around the acetylation site of K158. |
| Specificity | Acetyl-RIP140 (K158) Polyclonal Antibody detects endogenous levels of RIP140 around the acetylation site of K158 protein. |
Additional Info
| Function | Modulates transcriptional activation by steroid receptors such as NR3C1, NR3C2 and ESR1. Also modulates transcriptional repression by nuclear hormone receptors. Positive regulator of the circadian clock gene expression: stimulates transcription of BMAL1, CLOCK and CRY1 by acting as a coactivator for RORA and RORC. Involved in the regulation of ovarian function. Plays a role in renal development. |
| Protein Name | Nuclear Receptor-Interacting Protein 1Nuclear Factor Rip140Receptor-Interacting Protein 140 |
| Database Links | Reactome: R-HSA-3899300Reactome: R-HSA-400253Reactome: R-HSA-9018519Reactome: R-HSA-9029558Reactome: R-HSA-9632974Reactome: R-HSA-9707616 |
| Cellular Localisation | NucleusLocalized To Discrete Foci And Redistributes To Larger Nuclear Domains Upon Binding To Ligand-Bound Nr3c1 |
| Alternative Antibody Names | Anti-Nuclear Receptor-Interacting Protein 1 antibodyAnti-Nuclear Factor Rip140 antibodyAnti-Receptor-Interacting Protein 140 antibodyAnti-NRIP1 antibody |
Information sourced from Uniprot.org