Anti-Acetyl-MYB-Lys480 antibody (STJA0005979)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human c-Myb (Acetyl Lys480)
General Information
| Short Description | Rabbit polyclonal anti-Acetyl-Transcriptional activator Myb-Lys480 for use in WB and ELISA in Human and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit serum by affinity-chromatography using specific immunogen. |
| Dilution Range | WB 1:1000-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | MYB |
| Gene ID | 4602 |
| Uniprot ID | MYB_HUMAN |
| Immunogen | Synthesized peptide derived from human c-Myb (Acetyl Lys480) |
| Specificity | This antibody detects endogenous levels of Human, Mouse c-Myb (Acetyl Lys480) |
Additional Info
| Post Translational Modifications | Ubiquitinated.mediated by SIAH1 and leading to its subsequent proteasomal degradation. SUMOylated by TRAF7.leading to MYB transcriptional activity inhibition. Phosphorylated by NLK on multiple sites, which induces proteasomal degradation. Phosphorylated by HIPK1. This phosphorylation reduces MYB transcription factor activity but not MYB protein levels. |
| Function | Transcriptional activator.DNA-binding protein that specifically recognize the sequence 5'-YAACGTG-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells. |
| Protein Name | Transcriptional Activator MybProto-Oncogene C-Myb |
| Database Links | Reactome: R-HSA-8939236Reactome: R-HSA-9018519Reactome: R-HSA-9616222Reactome: R-HSA-983231Reactome: R-HSA-9834899 |
| Cellular Localisation | Nucleus |
| Alternative Antibody Names | Anti-Transcriptional Activator Myb antibodyAnti-Proto-Oncogene C-Myb antibodyAnti-MYB antibody |
Information sourced from Uniprot.org