| Host: |
Mouse |
| Applications: |
WB |
| Reactivity: |
Human, Mouse, Rat, Bovine |
| Note: |
FOR RESEARCH USE ONLY (RUO). |
| Short Description: |
Mouse monoclonal antibody anti-Angiotensin-Converting Enzyme (N-Term) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Conjugation: |
Unconjugated |
| Formulation: |
Buffer, 0.1M Tris-Glycine (pH 7.4, 150 mM NaCl) with 0.2% Sodium Azide, 50% Glycerol. |
| Purification: |
The antibody was isolated from ascitic fluid by immunoaffinity chromatography using antigens coupled to agarose beads. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:1000-1:2000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACE |
| Gene ID: |
1636 |
| Uniprot ID: |
ACE_HUMAN |
| Immunogen Region: |
N-Term |
| Specificity: |
ACE monoclonal antibody (Angiotensin-Converting Enzyme) binds to endogenous Angiotensin-Converting Enzyme at the amino acid region N-Term. |
| Immunogen: |
Purified recombinant human ACE1 (N-terminus) protein fragments expressed in E.coli. |
| Post Translational Modifications | Phosphorylated by CK2 on Ser-1299.which allows membrane retention. |
| Function | Converts angiotensin I to angiotensin II by release of the terminal His-Leu, this results in an increase of the vasoconstrictor activity of angiotensin. Also able to inactivate bradykinin, a potent vasodilator. Has also a glycosidase activity which releases GPI-anchored proteins from the membrane by cleaving the mannose linkage in the GPI moiety. |
| Protein Name | Angiotensin-Converting EnzymeAceDipeptidyl Carboxypeptidase IKininase IiCd Antigen Cd143 Cleaved Into - Angiotensin-Converting Enzyme - Soluble Form |
| Database Links | Reactome: R-HSA-2022377 |
| Cellular Localisation | Angiotensin-Converting EnzymeSoluble Form: SecretedCell MembraneSingle-Pass Type I Membrane ProteinCytoplasmDetected In Both Cell Membrane And Cytoplasm In Neurons |
| Alternative Antibody Names | Anti-Angiotensin-Converting Enzyme antibodyAnti-Ace antibodyAnti-Dipeptidyl Carboxypeptidase I antibodyAnti-Kininase Ii antibodyAnti-Cd Antigen Cd143 Cleaved Into - Angiotensin-Converting Enzyme - Soluble Form antibodyAnti-ACE antibodyAnti-DCP antibodyAnti-DCP1 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
