| Host: | Rabbit |
| Applications: | WB/ELISA |
| Reactivity: | Human |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | PBS with 0.05% Proclin300, 50% Glycerol, pH 7.3. |
| Purification: | Affinity purification |
| Concentration: | Lot specific |
| Dilution Range: | WB:1:500-1:1000 ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACD |
| Gene ID: | 65057 |
| Uniprot ID: | ACD_HUMAN |
| Immunogen Region: | 1-220 |
| Specificity: | Recombinant fusion protein containing a sequence corresponding to amino acids 1-220 of human ACD (NP_001075955.1). |
| Immunogen Sequence: | MPGRCQSDAAMRVNGPASRA PAGWTSGSLHTGPRAGRPRA QARGVRGRGLLLRPRPAKEL PLPRKGGAWAPAGNPGPLHP LGVAVGMAGSGRLVLRPWIR ELILGSETPSSPRAGQLLEV LQDAEAAVAGPSHAPDTSDV GATLLVSDGTHSVRCLVTRE ALDTSDWEEKEFGFRGTEGR LLLLQDCGVHVQVAEGGAPA EFYLQVDRFSLLPTEQPRLR |
| Function | Component of the shelterin complex (telosome) that is involved in the regulation of telomere length and protection. Shelterin associates with arrays of double-stranded TTAGGG repeats added by telomerase and protects chromosome ends. Without its protective activity, telomeres are no longer hidden from the DNA damage surveillance and chromosome ends are inappropriately processed by DNA repair pathways. Promotes binding of POT1 to single-stranded telomeric DNA. Modulates the inhibitory effects of POT1 on telomere elongation. The ACD-POT1 heterodimer enhances telomere elongation by recruiting telomerase to telomeres and increasing its processivity. May play a role in organogenesis. |
| Protein Name | Adrenocortical Dysplasia Protein Homolog Pot1 And Tin2-Interacting Protein |
| Database Links | Reactome: R-HSA-110328 Reactome: R-HSA-110329 Reactome: R-HSA-110330 Reactome: R-HSA-110331 Reactome: R-HSA-1221632 Reactome: R-HSA-171306 Reactome: R-HSA-171319 Reactome: R-HSA-174411 Reactome: R-HSA-174414 Reactome: R-HSA-174417 Reactome: R-HSA-174430 Reactome: R-HSA-174437 Reactome: R-HSA-2559586 Reactome: R-HSA-9670095 |
| Cellular Localisation | Nucleus Chromosome Telomere |
| Alternative Antibody Names | Anti-Adrenocortical Dysplasia Protein Homolog antibody Anti-Pot1 And Tin2-Interacting Protein antibody Anti-ACD antibody Anti-PIP1 antibody Anti-PTOP antibody Anti-TINT1 antibody Anti-TPP1 antibody |
Information sourced from Uniprot.org