| Host: |
Rabbit |
| Applications: |
IHC |
| Reactivity: |
Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-ACAN (420-575) is suitable for use in Immunohistochemistry research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.05% Proclin300, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
IHC-P 1:50-1:200 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ACAN |
| Gene ID: |
176 |
| Uniprot ID: |
PGCA_HUMAN |
| Immunogen Region: |
420-575 |
| Immunogen: |
Recombinant fusion protein containing a sequence corresponding to amino acids 420-575 of human Aggrecan (NP_037359.3). |
| Immunogen Sequence: |
FAPEIGATAFAEVENETGEA TRPWGFPTPGLGPATAFTSE DLVVQVTAVPGQPHLPGGVV FHYRPGPTRYSLTFEEAQQA CLRTGAVIASPEQLQAAYEA GYEQCDAGWLRDQTVRYPIV SPRTPCVGDKDSSPGVRTYG VRPSTETYDVYCFVDR |
| Tissue Specificity | Detected in fibroblasts (at protein level). Restricted to cartilage. |
| Post Translational Modifications | Contains mostly chondroitin sulfate, but also keratan sulfate chains, N-linked and O-linked oligosaccharides. The release of aggrecan fragments from articular cartilage into the synovial fluid at all stages of human osteoarthritis is the result of cleavage by aggrecanase. |
| Function | This proteoglycan is a major component of extracellular matrix of cartilagenous tissues. A major function of this protein is to resist compression in cartilage. It binds avidly to hyaluronic acid via an N-terminal globular region. |
| Protein Name | Aggrecan Core ProteinCartilage-Specific Proteoglycan Core ProteinCspcpChondroitin Sulfate Proteoglycan Core Protein 1Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 |
| Database Links | Reactome: R-HSA-1474228Reactome: R-HSA-2022854Reactome: R-HSA-2022857Reactome: R-HSA-3000178Reactome: R-HSA-3656225Reactome: R-HSA-3656243Reactome: R-HSA-3656244 |
| Cellular Localisation | SecretedExtracellular SpaceExtracellular Matrix |
| Alternative Antibody Names | Anti-Aggrecan Core Protein antibodyAnti-Cartilage-Specific Proteoglycan Core Protein antibodyAnti-Cspcp antibodyAnti-Chondroitin Sulfate Proteoglycan Core Protein 1 antibodyAnti-Chondroitin Sulfate Proteoglycan 1 Cleaved Into - Aggrecan Core Protein 2 antibodyAnti-ACAN antibodyAnti-AGC1 antibodyAnti-CSPG1 antibodyAnti-MSK16 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
