| Tissue Specificity | Predominantly expressed in heart and skeletal muscle (at protein level). Also detected in kidney and liver (at protein level). |
| Post Translational Modifications | S-nitrosylation at Cys-237 in liver improves catalytic efficiency. |
| Function | Very long-chain specific acyl-CoA dehydrogenase is one of the acyl-CoA dehydrogenases that catalyze the first step of mitochondrial fatty acid beta-oxidation, an aerobic process breaking down fatty acids into acetyl-CoA and allowing the production of energy from fats. The first step of fatty acid beta-oxidation consists in the removal of one hydrogen from C-2 and C-3 of the straight-chain fatty acyl-CoA thioester, resulting in the formation of trans-2-enoyl-CoA. Among the different mitochondrial acyl-CoA dehydrogenases, very long-chain specific acyl-CoA dehydrogenase acts specifically on acyl-CoAs with saturated 12 to 24 carbons long primary chains. |
| Protein Name | Very Long-Chain Specific Acyl-Coa Dehydrogenase - MitochondrialVlcad |
| Database Links | Reactome: R-HSA-381038Reactome: R-HSA-77305 |
| Cellular Localisation | Mitochondrion Inner MembranePeripheral Membrane ProteinIsoform 2: Mitochondrion Inner Membrane |
| Alternative Antibody Names | Anti-Very Long-Chain Specific Acyl-Coa Dehydrogenase - Mitochondrial antibodyAnti-Vlcad antibodyAnti-ACADVL antibodyAnti-VLCAD antibody |
Information sourced from Uniprot.org
