| Host: | Rabbit |
| Applications: | WB/IHC/IF/ELISA |
| Reactivity: | Human/Mouse/Rat/Cow/Dog |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-Acetyl-CoA carboxylase 1 (46-95 aa) is suitable for use in Western Blot, Immunohistochemistry, Immunofluorescence and ELISA research applications. |
| Clonality : | Polyclonal |
| Conjugation: | Unconjugated |
| Isotype: | IgG |
| Formulation: | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: | 1 mg/mL |
| Dilution Range: | WB 1:500-1:2000 IHC 1:100-1:300 ELISA 1:5000 IF 1:50-200 |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ACACA |
| Gene ID: | 31 |
| Uniprot ID: | ACACA_HUMAN |
| Immunogen Region: | 46-95 aa |
| Specificity: | ACC Alpha Polyclonal Antibody detects endogenous levels of ACC Alpha protein. |
| Immunogen: | The antiserum was produced against synthesized peptide derived from the human Acetyl-CoA Carboxylase at the amino acid range 46-95 |
| Post Translational Modifications | Phosphorylation on Ser-1263 is required for interaction with BRCA1. Phosphorylation at Ser-80 by AMPK inactivates enzyme activity. The biotin cofactor is covalently attached to the central biotinyl-binding domain and is required for the catalytic activity. |
| Function | Cytosolic enzyme that catalyzes the carboxylation of acetyl-CoA to malonyl-CoA, the first and rate-limiting step of de novo fatty acid biosynthesis. This is a 2 steps reaction starting with the ATP-dependent carboxylation of the biotin carried by the biotin carboxyl carrier (BCC) domain followed by the transfer of the carboxyl group from carboxylated biotin to acetyl-CoA. |
| Protein Name | Acetyl-Coa Carboxylase 1 Acc1 Acetyl-Coenzyme A Carboxylase Alpha Acc-Alpha |
| Database Links | Reactome: R-HSA-163765 Reactome: R-HSA-196780 Reactome: R-HSA-200425 Reactome: R-HSA-2426168 Reactome: R-HSA-3371599 Reactome: R-HSA-75105 |
| Cellular Localisation | Cytoplasm Cytosol |
| Alternative Antibody Names | Anti-Acetyl-Coa Carboxylase 1 antibody Anti-Acc1 antibody Anti-Acetyl-Coenzyme A Carboxylase Alpha antibody Anti-Acc-Alpha antibody Anti-ACACA antibody Anti-ACAC antibody Anti-ACC1 antibody Anti-ACCA antibody |
Information sourced from Uniprot.org