Anti-ACAA2 antibody [R35-1Y-2] (STJA0035516)
SPECIFICATIONS
ClonalityMonoclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthesized peptide derived from human ACAA2
General Information
| Short Description | Rabbit monoclonal anti-ACAA2 for use in WB, IHC-P, ICC and IF in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/ICC/IF |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Monoclonal |
| Clone ID | R35-1Y-2 |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | Affinity Chromatography |
| Dilution Range | WB 1:500-1:1000IHC 1:100-1:200IF 1:50-1:200 |
| Formulation | Liquid in PBS, pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol. |
| Storage Instruction | Store at 4°C short term. Aliquot and store at-20°C long term. Avoid freeze/thaw cycles. |
Target Information
| Gene Symbol | ACAA2 |
| Gene ID | 10449 |
| Uniprot ID | THIM_HUMAN |
| Immunogen | A synthesized peptide derived from human ACAA2 |
Additional Info
| Function | In the production of energy from fats, this is one of the enzymes that catalyzes the last step of the mitochondrial beta-oxidation pathway, an aerobic process breaking down fatty acids into acetyl-CoA (Probable). Using free coenzyme A/CoA, catalyzes the thiolytic cleavage of medium- to long-chain unbranched 3-oxoacyl-CoAs into acetyl-CoA and a fatty acyl-CoA shortened by two carbon atoms (Probable). Also catalyzes the condensation of two acetyl-CoA molecules into acetoacetyl-CoA and could be involved in the production of ketone bodies (Probable). Also displays hydrolase activity on various fatty acyl-CoAs. Thereby, could be responsible for the production of acetate in a side reaction to beta-oxidation (Probable). Abolishes BNIP3-mediated apoptosis and mitochondrial damage. |
| Protein Name | 3-Ketoacyl-Coa Thiolase - MitochondrialAcetyl-Coa AcetyltransferaseAcetyl-Coa AcyltransferaseAcyl-Coa Hydrolase - MitochondrialBeta-KetothiolaseMitochondrial 3-Oxoacyl-Coa ThiolaseT1 |
| Database Links | Reactome: R-HSA-77289 |
| Cellular Localisation | Mitochondrion |
| Alternative Antibody Names | Anti-3-Ketoacyl-Coa Thiolase - Mitochondrial antibodyAnti-Acetyl-Coa Acetyltransferase antibodyAnti-Acetyl-Coa Acyltransferase antibodyAnti-Acyl-Coa Hydrolase - Mitochondrial antibodyAnti-Beta-Ketothiolase antibodyAnti-Mitochondrial 3-Oxoacyl-Coa Thiolase antibodyAnti-T1 antibodyAnti-ACAA2 antibody |
Information sourced from Uniprot.org