| Host: | Rabbit |
| Applications: | ELISA/IP/WB |
| Reactivity: | Human/Monkey |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description : | Rabbit polyclonal antibody anti-ABRAXAS1 (350-400) is suitable for use in ELISA, Immunoprecipitation and Western Blot research applications. |
| Clonality : | Polyclonal |
| Conjugation: | FITC |
| Isotype: | IgG |
| Formulation: | Contains Tris, HCl/Glycine buffer pH 7.4-7.8, 30% Glycerol and 0.5% BSA, along with cryo-protective agents, Hepes, and long-term preservatives (0.02% Sodium Azide). |
| Purification: | Affinity Purified |
| Concentration: | 0.52-0.63 µg/µl |
| Dilution Range: | WB: 1:500 DB: 1:10, 000 ELISA: 1:10, 000 IP: 1:200 |
| Storage Instruction: | Store at-20°C for long term storage. Avoid freeze-thaw cycles. |
| Gene Symbol: | ABRAXAS1 |
| Gene ID: | 84142 |
| Uniprot ID: | ABRX1_HUMAN |
| Immunogen Region: | 350-400 |
| Immunogen: | Synthetic peptide taken within amino acid region 350-400 on human BRCA1-A complex subunit Abraxas protein. |
| Post Translational Modifications | Phosphorylation of Ser-406 of the pSXXF motif by ATM or ATR constitutes a specific recognition motif for the BRCT domain of BRCA1. Ionizing radiation promotes rapid phosphorylation at Ser-404 and Ser-406 by ATM.this promotes recruitment of BRCA1 to sites of DNA damage. |
| Function | Involved in DNA damage response and double-strand break (DSB) repair. Component of the BRCA1-A complex, acting as a central scaffold protein that assembles the various components of the complex and mediates the recruitment of BRCA1. The BRCA1-A complex specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesion sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at DSBs. This complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. |
| Protein Name | Brca1-A Complex Subunit Abraxas 1 Coiled-Coil Domain-Containing Protein 98 Protein Fam175a |
| Database Links | Reactome: R-HSA-5689901 Reactome: R-HSA-5693565 Reactome: R-HSA-5693571 Reactome: R-HSA-5693607 Reactome: R-HSA-69473 |
| Cellular Localisation | Nucleus Localizes At Sites Of Dna Damage At Double-Strand Breaks (Dsbs) |
| Alternative Antibody Names | Anti-Brca1-A Complex Subunit Abraxas 1 antibody Anti-Coiled-Coil Domain-Containing Protein 98 antibody Anti-Protein Fam175a antibody Anti-ABRAXAS1 antibody Anti-ABRA1 antibody Anti-CCDC98 antibody Anti-FAM175A antibody Anti-UNQ496 antibody Anti-PRO1013 antibody |
Information sourced from Uniprot.org