| Host: |
Rabbit |
| Applications: |
WB |
| Reactivity: |
Human/Mouse/Rat |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit monoclonal antibody anti-ABL2 (500-600) is suitable for use in Western Blot research applications. |
| Clonality: |
Monoclonal |
| Clone ID: |
S0MR |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
PBS with 0.02% Sodium Azide, 0.05% BSA, 50% Glycerol, pH7.3. |
| Purification: |
Affinity purification |
| Dilution Range: |
WB 1:500-1:1000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABL2 |
| Gene ID: |
27 |
| Uniprot ID: |
ABL2_HUMAN |
| Immunogen Region: |
500-600 |
| Immunogen: |
A synthetic peptide corresponding to a sequence within amino acids 500-600 of human ABL2 (P42684). |
| Immunogen Sequence: |
KGYRMEQPEGCPPKVYELMR ACWKWSPADRPSFAETHQAF ETMFHDSSISEEVAEELGRA ASSSSVVPYLPRLPILPSKT RTLKKQVENKENIEGAQDAT E |
| Tissue Specificity | Widely expressed. |
| Post Translational Modifications | Phosphorylated at Tyr-261 by ABL1 in response to oxidative stress. Phosphorylated by PDGFRB. Polyubiquitinated. Polyubiquitination of ABL2 leads to degradation. |
| Function | Non-receptor tyrosine-protein kinase that plays an ABL1-overlapping role in key processes linked to cell growth and survival such as cytoskeleton remodeling in response to extracellular stimuli, cell motility and adhesion and receptor endocytosis. Coordinates actin remodeling through tyrosine phosphorylation of proteins controlling cytoskeleton dynamics like MYH10 (involved in movement).CTTN (involved in signaling).or TUBA1 and TUBB (microtubule subunits). Binds directly F-actin and regulates actin cytoskeletal structure through its F-actin-bundling activity. Involved in the regulation of cell adhesion and motility through phosphorylation of key regulators of these processes such as CRK, CRKL, DOK1 or ARHGAP35. Adhesion-dependent phosphorylation of ARHGAP35 promotes its association with RASA1, resulting in recruitment of ARHGAP35 to the cell periphery where it inhibits RHO. Phosphorylates multiple receptor tyrosine kinases like PDGFRB and other substrates which are involved in endocytosis regulation such as RIN1. In brain, may regulate neurotransmission by phosphorylating proteins at the synapse. ABL2 acts also as a regulator of multiple pathological signaling cascades during infection. Pathogens can highjack ABL2 kinase signaling to reorganize the host actin cytoskeleton for multiple purposes, like facilitating intracellular movement and host cell exit. Finally, functions as its own regulator through autocatalytic activity as well as through phosphorylation of its inhibitor, ABI1. Positively regulates chemokine-mediated T-cell migration, polarization, and homing to lymph nodes and immune-challenged tissues, potentially via activation of NEDD9/HEF1 and RAP1. |
| Protein Name | Tyrosine-Protein Kinase Abl2Abelson Murine Leukemia Viral Oncogene Homolog 2Abelson Tyrosine-Protein Kinase 2Abelson-Related Gene ProteinTyrosine-Protein Kinase Arg |
| Database Links | Reactome: R-HSA-428890Reactome: R-HSA-9013149Reactome: R-HSA-9013423Reactome: R-HSA-9706369 |
| Cellular Localisation | CytoplasmCytoskeleton |
| Alternative Antibody Names | Anti-Tyrosine-Protein Kinase Abl2 antibodyAnti-Abelson Murine Leukemia Viral Oncogene Homolog 2 antibodyAnti-Abelson Tyrosine-Protein Kinase 2 antibodyAnti-Abelson-Related Gene Protein antibodyAnti-Tyrosine-Protein Kinase Arg antibodyAnti-ABL2 antibodyAnti-ABLL antibodyAnti-ARG antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
