| Host: |
Rabbit |
| Applications: |
WB/IF/ELISA |
| Reactivity: |
Human/Mouse |
| Note: |
STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Short Description: |
Rabbit polyclonal antibody anti-Monoacylglycerol lipase ABHD2 (251-300 aa) is suitable for use in Western Blot, Immunofluorescence and ELISA research applications. |
| Clonality: |
Polyclonal |
| Conjugation: |
Unconjugated |
| Isotype: |
IgG |
| Formulation: |
Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Purification: |
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Concentration: |
1 mg/mL |
| Dilution Range: |
WB 1:500-1:2000IF 1:200-1:1000ELISA 1:40000 |
| Storage Instruction: |
Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: |
ABHD2 |
| Gene ID: |
11057 |
| Uniprot ID: |
ABHD2_HUMAN |
| Immunogen Region: |
251-300 aa |
| Specificity: |
ABHD2 Polyclonal Antibody detects endogenous levels of ABHD2 protein. |
| Immunogen: |
The antiserum was produced against synthesized peptide derived from the human ABHD2 at the amino acid range 251-300 |
| Function | Progesterone-dependent acylglycerol lipase that catalyzes hydrolysis of endocannabinoid arachidonoylglycerol (AG) from cell membrane. Acts as a progesterone receptor: progesterone-binding activates the acylglycerol lipase activity, mediating degradation of 1-arachidonoylglycerol (1AG) and 2-arachidonoylglycerol (2AG) to glycerol and arachidonic acid (AA). Also displays an ester hydrolase activity against acetyl ester, butanoate ester and hexadecanoate ester. Plays a key role in sperm capacitation in response to progesterone by mediating degradation of 2AG, an inhibitor of the sperm calcium channel CatSper, leading to calcium influx via CatSper and sperm activation. May also play a role in smooth muscle cells migration. |
| Protein Name | Monoacylglycerol Lipase Abhd22-Arachidonoylglycerol HydrolaseAbhydrolase Domain-Containing Protein 2AcetylesteraseLung Alpha/Beta Hydrolase 2Progesterone-Sensitive LipaseProtein Phps1-2 |
| Cellular Localisation | Cell ProjectionCiliumFlagellum MembraneSingle-Pass Type Ii Membrane ProteinCell Membrane |
| Alternative Antibody Names | Anti-Monoacylglycerol Lipase Abhd2 antibodyAnti-2-Arachidonoylglycerol Hydrolase antibodyAnti-Abhydrolase Domain-Containing Protein 2 antibodyAnti-Acetylesterase antibodyAnti-Lung Alpha/Beta Hydrolase 2 antibodyAnti-Progesterone-Sensitive Lipase antibodyAnti-Protein Phps1-2 antibodyAnti-ABHD2 antibodyAnti-LABH2 antibody |
Information sourced from Uniprot.org
12 months for antibodies. 6 months for ELISA Kits. Please see website T&Cs for further guidance
