Anti-ABHD12 antibody (110-250) (STJ11102925)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ABHD12 (110-250) antibody for use in WB and ELISA in human and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.01% Thimerosal, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABHD12 |
| Gene ID | 26090 |
| Uniprot ID | ABD12_HUMAN |
| Immunogen Region | 110-250 |
| Immunogen Sequence | YFIDLKKPQDQGLNHTCNYY LQPEEDVTIGVWHTVPAVWW KNAQGKDQMWYEDALASSHP IILYLHGNAGTRGGDHRVEL YKVLSSLGYHVVTFDYRGWG DSVGTPSERGMTYDALHVFD WIKARSGDNPVYIWGHSLGT G |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 110-250 of human ABHD12 (NP_056415.1). |
Additional Info
| Post Translational Modifications | Glycosylated.glycosylation is required for optimal activity. |
| Function | Lysophosphatidylserine (LPS) lipase that mediates the hydrolysis of lysophosphatidylserine, a class of signaling lipids that regulates immunological and neurological processes. Represents a major lysophosphatidylserine lipase in the brain, thereby playing a key role in the central nervous system. Also able to hydrolyze oxidized phosphatidylserine.oxidized phosphatidylserine is produced in response to severe inflammatory stress and constitutes a proapoptotic 'eat me' signal. Also has monoacylglycerol (MAG) lipase activity: hydrolyzes 2-arachidonoylglycerol (2-AG), thereby acting as a regulator of endocannabinoid signaling pathways. Has a strong preference for very-long-chain lipid substrates.substrate specificity is likely due to improved catalysis and not improved substrate binding. |
| Protein Name | Lysophosphatidylserine Lipase Abhd122-Arachidonoylglycerol Hydrolase Abhd12Abhydrolase Domain-Containing Protein 12Habhd12Monoacylglycerol Lipase Abhd12Oxidized Phosphatidylserine Lipase Abhd12 |
| Database Links | Reactome: R-HSA-426048 |
| Cellular Localisation | Endoplasmic Reticulum MembraneSingle-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Lysophosphatidylserine Lipase Abhd12 antibodyAnti-2-Arachidonoylglycerol Hydrolase Abhd12 antibodyAnti-Abhydrolase Domain-Containing Protein 12 antibodyAnti-Habhd12 antibodyAnti-Monoacylglycerol Lipase Abhd12 antibodyAnti-Oxidized Phosphatidylserine Lipase Abhd12 antibodyAnti-ABHD12 antibodyAnti-C20orf22 antibody |
Information sourced from Uniprot.org