| Short Description : | Rabbit polyclonal anti-ATP-binding cassette sub-family G member 4 (540-620 aa) for use in WB and ELISA in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications: | WB/ELISA |
| Host: | Rabbit |
| Reactivity: | Human/Rat/Mouse |
| Note: | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
| Clonality : | Polyclonal |
| Isotype: | IgG |
| Conjugation: | Unconjugated |
| Concentration: | 1 mg/mL |
| Purification: | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range: | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation: | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction: | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
| Gene Symbol: | ABCG4 |
| Gene ID: | 64137 |
| Uniprot ID: | ABCG4_HUMAN |
| Immunogen: | Synthesized peptide derived from the human protein at the amino acid range 540-620 |
| Immunogen Region: | 540-620 aa |
| Specificity: | ABCG4 Polyclonal Antibody detects endogenous levels of protein. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that may be involved in the cellular efflux of sterols, in particular cholesterol and desmosterol (a cholesterol precursor), to high-density lipoprotein (HDL). May play an important role in the removal of amyloid-beta peptides from brain, in a process that can be antagonized by desmosterol. However it is unclear whether ABCG4 can directly transport amyloid-beta peptides or whether peptide export may be facilitated due to changes in the membrane lipid environment. Induces apoptosis in various cells. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 4 |
| Database Links | Reactome: R-HSA-1369062 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane ProteinCytoplasmic Vesicle MembraneEndosome Membrane |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 4 antibodyAnti-ABCG4 antibodyAnti-WHITE2 antibody |
Information sourced from Uniprot.org
