Anti-ABCG1 antibody (350-400 aa) (STJ13100660)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 350-400 of human ABCG1 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ABCG1 (350-400 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB. A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20°C for long term storage and refrigerated at 2-8°C for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ABCG1 |
| Gene ID | 9619 |
| Uniprot ID | ABCG1_HUMAN |
| Immunogen | A synthetic peptide from aa region 350-400 of human ABCG1 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 350-400 aa |
| Specificity | Specific for ABCG1. |
Additional Info
| Post Translational Modifications | Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. |
| Function | Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrolysis of ATP. The lipid efflux is ALB-dependent. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol. |
| Protein Name | Atp-Binding Cassette Sub-Family G Member 1Atp-Binding Cassette Transporter 8White Protein Homolog |
| Database Links | Reactome: R-HSA-1369062Reactome: R-HSA-8964058Reactome: R-HSA-9029569 |
| Cellular Localisation | Endoplasmic Reticulum MembraneMulti-Pass Membrane ProteinGolgi Apparatus MembraneCell MembranePredominantly Localized In The Intracellular Compartments Mainly Associated With The Endoplasmic Reticulum (Er) And Golgi Membranes |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family G Member 1 antibodyAnti-Atp-Binding Cassette Transporter 8 antibodyAnti-White Protein Homolog antibodyAnti-ABCG1 antibodyAnti-ABC8 antibodyAnti-WHT1 antibody |
Information sourced from Uniprot.org