Anti-ABCE1 antibody (STJA0009209)

SKU:
STJA0009209

Current Stock:
Host: Rabbit
Applications: WB
Reactivity: Human/Mouse
Note: STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS.
Short Description: Rabbit polyclonal antibody anti-ATP-binding cassette sub-family E member 1 is suitable for use in Western Blot research applications.
Clonality: Polyclonal
Conjugation: Unconjugated
Isotype: IgG
Formulation: Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide.
Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration: 1 mg/mL
Dilution Range: WB 1:500-2000
Storage Instruction: Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles.
Gene Symbol: ABCE1
Gene ID: 6059
Uniprot ID: ABCE1_HUMAN
Specificity: This antibody detects endogenous levels of ABCE1 at Human, Mouse
Immunogen: Synthesized peptide derived from human ABCE1
Function Nucleoside-triphosphatase (NTPase) involved in ribosome recycling by mediating ribosome disassembly. Able to hydrolyze ATP, GTP, UTP and CTP. Splits ribosomes into free 60S subunits and tRNA- and mRNA-bound 40S subunits. Acts either after canonical termination facilitated by release factors (ETF1/eRF1) or after recognition of stalled and vacant ribosomes by mRNA surveillance factors (PELO/Pelota). Involved in the No-Go Decay (NGD) pathway: recruited to stalled ribosomes by the Pelota-HBS1L complex, and drives the disassembly of stalled ribosomes, followed by degradation of damaged mRNAs as part of the NGD pathway. Also plays a role in quality control of translation of mitochondrial outer membrane-localized mRNA. As part of the PINK1-regulated signaling, ubiquitinated by CNOT4 upon mitochondria damage.this modification generates polyubiquitin signals that recruit autophagy receptors to the mitochondrial outer membrane and initiate mitophagy. RNASEL-specific protein inhibitor which antagonizes the binding of 2-5A (5'-phosphorylated 2',5'-linked oligoadenylates) to RNASEL. Negative regulator of the anti-viral effect of the interferon-regulated 2-5A/RNASEL pathway. (Microbial infection) May act as a chaperone for post-translational events during HIV-1 capsid assembly. (Microbial infection) Plays a role in the down-regulation of the 2-5A/RNASEL pathway during encephalomyocarditis virus (EMCV) and HIV-1 infections.
Protein Name Atp-Binding Cassette Sub-Family E Member 1
2'-5'-Oligoadenylate-Binding Protein
Huhp68
Rnase L Inhibitor
Ribonuclease 4 Inhibitor
Rns4i
Database Links Reactome: R-HSA-8983711
Reactome: R-HSA-909733
Cellular Localisation Cytoplasm
Mitochondrion
Alternative Antibody Names Anti-Atp-Binding Cassette Sub-Family E Member 1 antibody
Anti-2'-5'-Oligoadenylate-Binding Protein antibody
Anti-Huhp68 antibody
Anti-Rnase L Inhibitor antibody
Anti-Ribonuclease 4 Inhibitor antibody
Anti-Rns4i antibody
Anti-ABCE1 antibody
Anti-RLI antibody
Anti-RNASEL1 antibody
Anti-RNASELI antibody
Anti-RNS4I antibody
Anti-OK antibody
Anti-SW-cl.40 antibody

Information sourced from Uniprot.org

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