Anti-ABCC8 antibody (700-1000) (STJ110754)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ABCC8 (700-1000) antibody for use in WB and ELISA in mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCC8 |
| Gene ID | 6833 |
| Uniprot ID | ABCC8_HUMAN |
| Immunogen Region | 700-1000 |
| Immunogen Sequence | TIRIPRGQLTMIVGQVGCGK SSLLLAALGEMQKVSGAVFW SSLPDSEIGEDPSPERETAT DLDIRKRGPVAYASQKPWLL NATVEENIIFESPFNKQRYK MVIEACSLQPDIDILPHGDQ TQIGERGINLSGGQRQRISV ARALYQHANVVFLDDPFSAL DIHLSDHLMQAGILELLRDD KRTVVLVTHKLQYLPHADWI IAMKDGTIQREGTLKDFQRS ECQLFEHWKTLMNRQDQEL |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 700-1000 of human ABCC8 (NP_000343.2). |
Additional Info
| Function | Regulator subunit of pancreatic ATP-sensitive potassium channel (KATP), playing a major role in the regulation of insulin release. In pancreatic cells, it forms KATP channels with KCNJ11.KCNJ11 forms the channel pore while ABCC8 is required for activation and regulation. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 8Sulfonylurea Receptor 1 |
| Database Links | Reactome: R-HSA-1296025Reactome: R-HSA-422356Reactome: R-HSA-5683177 |
| Cellular Localisation | Cell MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 8 antibodyAnti-Sulfonylurea Receptor 1 antibodyAnti-ABCC8 antibodyAnti-HRINS antibodyAnti-SUR antibodyAnti-SUR1 antibody |
Information sourced from Uniprot.org