Anti-ABCC4 antibody (884-934) (STJA0006675)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from human MRP4 AA range: 884-934
General Information
| Short Description | Rabbit polyclonal anti-ATP-binding cassette sub-family C member 4 (884-934) for use in WB in Human, Rat and Mouse samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB |
| Host | Rabbit |
| Reactivity | Human/Rat/Mouse |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:1000-2000 |
| Formulation | Liquid in PBS containing 50% Glycerol, 0.5% BSA and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCC4 |
| Gene ID | 10257 |
| Uniprot ID | MRP4_HUMAN |
| Immunogen | Synthesized peptide derived from human MRP4 AA range: 884-934 |
| Immunogen Region | 884-934 |
| Specificity | This antibody detects endogenous levels of human MRP4 |
Additional Info
| Post Translational Modifications | N-glycosylated.leading to substrate-selective effects on its transport activity. |
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins. Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4. Mediates the cotransport of bile acids with reduced glutathione (GSH). Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules. Confers resistance to anticancer agents such as methotrexate. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 4 Mrp/Cmoat-Related Abc TransporterMulti-Specific Organic Anion Transporter BMoat-BMultidrug Resistance-Associated Protein 4 |
| Database Links | Reactome: R-HSA-114608Reactome: R-HSA-382556Reactome: R-HSA-9748787Reactome: R-HSA-9753281 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinApical Cell MembraneIts Localization To The Basolateral Or Apical Membranes Is Tissue-Dependent |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 4 antibodyAnti-Mrp/Cmoat-Related Abc Transporter antibodyAnti-Multi-Specific Organic Anion Transporter B antibodyAnti-Moat-B antibodyAnti-Multidrug Resistance-Associated Protein 4 antibodyAnti-ABCC4 antibodyAnti-MOATB antibodyAnti-MRP4 antibody |
Information sourced from Uniprot.org