Anti-ABCC3/MRP3 antibody [SAA1949] (STJA0020377)
SPECIFICATIONS
ClonalityMonoclonal
HostMouse
ConjugationUnconjugated
IsotypeIgG2a
General Information
| Short Description | Mouse monoclonal Atp-Binding Cassette Sub-Family C Member 3 antibody for use in ELISA in human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | ELISA |
| Host | Mouse |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO) MUST NOT BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS |
Product Properties
| Clonality | Monoclonal |
| Clone ID | SAA1949 |
| Isotype | IgG2a |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | Protein A/G purified from cell culture supernatant |
| Formulation | 0.01M PBS, pH 7.4. |
| Storage Instruction | Suitable for storage at +4°C between 1-2 weeks For longer term store at-20°C for up to 12 months |
Target Information
| Gene Symbol | ABCC3 |
| Gene ID | 8714 |
| Uniprot ID | MRP3_HUMAN |
Additional Info
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports glucuronide conjugates such as bilirubin diglucuronide, estradiol-17-beta-o-glucuronide and GSH conjugates such as leukotriene C4 (LTC4). Transports also various bile salts (taurocholate, glycocholate, taurochenodeoxycholate-3-sulfate, taurolithocholate- 3-sulfate). Does not contribute substantially to bile salt physiology but provides an alternative route for the export of bile acids and glucuronides from cholestatic hepatocytes. May contribute to regulate the transport of organic compounds in testes across the blood-testis-barrier (Probable). Can confer resistance to various anticancer drugs, methotrexate, tenoposide and etoposide, by decreasing accumulation of these drugs in cells. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 3 Canalicular Multispecific Organic Anion Transporter 2Multi-Specific Organic Anion Transporter DMoat-DMultidrug Resistance-Associated Protein 3 |
| Database Links | Reactome: R-HSA-159418Reactome: R-HSA-382556Reactome: R-HSA-9749641Reactome: R-HSA-9753281Reactome: R-HSA-9818032 |
| Cellular Localisation | Basolateral Cell MembraneMulti-Pass Membrane ProteinBasal Cell MembraneLocalized To The Basolateral Membrane Of EnterocytesLocalized To The Basal Membrane Of Sertoli Cells |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 3 antibodyAnti-Canalicular Multispecific Organic Anion Transporter 2 antibodyAnti-Multi-Specific Organic Anion Transporter D antibodyAnti-Moat-D antibodyAnti-Multidrug Resistance-Associated Protein 3 antibodyAnti-ABCC3 antibodyAnti-CMOAT2 antibodyAnti-MLP2 antibodyAnti-MRP3 antibody |
Information sourced from Uniprot.org