Anti-ABCC2 antibody (900-950 aa) (STJ13100700)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenA synthetic peptide from aa region 900-950 of human ABCC2 conjugated to an immunogenic carrier protein was used as the antigen.
General Information
| Short Description | Rabbit polyclonal anti-ABCC2 (900-950 aa) for use in IHC and WB in Human samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | IHC/WB |
| Host | Rabbit |
| Reactivity | Human |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Purification | IgG purified |
| Dilution Range | IHC, WB (recombinant protein). A dilution of 1:300 to 1:2000 is recommended. The optimal dilution should be determined by the end user. Not yet tested in other applications. |
| Formulation | Lyophilised |
| Storage Instruction | Maintain the lyophilised/reconstituted antibodies frozen at-20ยฐC for long term storage and refrigerated at 2-8ยฐC for a shorter term. When reconstituting, Glycerol (1:1) may be added for an additional stability. Avoid freeze and thaw cycles. |
Target Information
| Gene Symbol | ABCC2 |
| Gene ID | 1244 |
| Uniprot ID | MRP2_HUMAN |
| Immunogen | A synthetic peptide from aa region 900-950 of human ABCC2 conjugated to an immunogenic carrier protein was used as the antigen. |
| Immunogen Region | 900-950 aa |
| Specificity | Specific for ABCC2. |
Additional Info
| Function | ATP-dependent transporter of the ATP-binding cassette (ABC) family that binds and hydrolyzes ATP to enable active transport of various substrates including many drugs, toxicants and endogenous compound across cell membranes. Transports a wide variety of conjugated organic anions such as sulfate-, glucuronide- and glutathione (GSH)-conjugates of endo- and xenobiotics substrates. Mediates hepatobiliary excretion of mono- and bis-glucuronidated bilirubin molecules and therefore play an important role in bilirubin detoxification. Also mediates hepatobiliary excretion of others glucuronide conjugates such as 17beta-estradiol 17-glucosiduronic acid and leukotriene C4. Transports sulfated bile salt such as taurolithocholate sulfate. Transports various anticancer drugs, such as anthracycline, vinca alkaloid and methotrexate and HIV-drugs such as protease inhibitors. Confers resistance to several anti-cancer drugs including cisplatin, doxorubicin, epirubicin, methotrexate, etoposide and vincristine. |
| Protein Name | Atp-Binding Cassette Sub-Family C Member 2 Canalicular Multidrug Resistance ProteinCanalicular Multispecific Organic Anion Transporter 1Multidrug Resistance-Associated Protein 2 |
| Database Links | Reactome: R-HSA-189483Reactome: R-HSA-382556Reactome: R-HSA-5679001Reactome: R-HSA-9749641Reactome: R-HSA-9753281Reactome: R-HSA-9754706 |
| Cellular Localisation | Apical Cell MembraneMulti-Pass Membrane ProteinLocalized To The Apical Membrane Of Enterocytes |
| Alternative Antibody Names | Anti-Atp-Binding Cassette Sub-Family C Member 2 antibodyAnti-Canalicular Multidrug Resistance Protein antibodyAnti-Canalicular Multispecific Organic Anion Transporter 1 antibodyAnti-Multidrug Resistance-Associated Protein 2 antibodyAnti-ABCC2 antibodyAnti-CMOAT antibodyAnti-CMOAT1 antibodyAnti-CMRP antibodyAnti-MRP2 antibody |
Information sourced from Uniprot.org