Anti-ABCB8 antibody (510-590 aa) (STJ190581)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
ImmunogenSynthesized peptide derived from the human protein at the amino acid range 510-590
General Information
| Short Description | Rabbit polyclonal anti-Mitochondrial potassium channel ATP-binding subunit (510-590 aa) for use in WB and ELISA in Human, Mouse and Rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | 1 mg/mL |
| Purification | The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. |
| Dilution Range | WB 1:500-2000ELISA 1:5000-20000 |
| Formulation | Liquid in PBS containing 50% Glycerol and 0.02% Sodium Azide. |
| Storage Instruction | Store at-20ยฐC for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCB8 |
| Gene ID | 11194 |
| Uniprot ID | MITOS_HUMAN |
| Immunogen | Synthesized peptide derived from the human protein at the amino acid range 510-590 |
| Immunogen Region | 510-590 aa |
| Specificity | ABCB8 Polyclonal Antibody detects endogenous levels of protein. |
Additional Info
| Function | ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes. |
| Protein Name | Mitochondrial Potassium Channel Atp-Binding SubunitAtp-Binding Cassette Sub-Family B Member 8 - MitochondrialAbcb8Mitochondrial Atp-Binding Cassette 1M-Abc1Mitochondrial Sulfonylurea-ReceptorMitosur |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Potassium Channel Atp-Binding Subunit antibodyAnti-Atp-Binding Cassette Sub-Family B Member 8 - Mitochondrial antibodyAnti-Abcb8 antibodyAnti-Mitochondrial Atp-Binding Cassette 1 antibodyAnti-M-Abc1 antibodyAnti-Mitochondrial Sulfonylurea-Receptor antibodyAnti-Mitosur antibodyAnti-ABCB8 antibodyAnti-MABC1 antibodyAnti-MITOSUR antibody |
Information sourced from Uniprot.org