| Function | ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes. |
| Protein Name | Mitochondrial Potassium Channel Atp-Binding SubunitAtp-Binding Cassette Sub-Family B Member 8 - MitochondrialAbcb8Mitochondrial Atp-Binding Cassette 1M-Abc1Mitochondrial Sulfonylurea-ReceptorMitosur |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Potassium Channel Atp-Binding Subunit antibodyAnti-Atp-Binding Cassette Sub-Family B Member 8 - Mitochondrial antibodyAnti-Abcb8 antibodyAnti-Mitochondrial Atp-Binding Cassette 1 antibodyAnti-M-Abc1 antibodyAnti-Mitochondrial Sulfonylurea-Receptor antibodyAnti-Mitosur antibodyAnti-ABCB8 antibodyAnti-MABC1 antibodyAnti-MITOSUR antibody |
Information sourced from Uniprot.org
