Anti-ABCB8 antibody (469-718) (STJ22457)
SPECIFICATIONS
ClonalityPolyclonal
HostRabbit
ConjugationUnconjugated
IsotypeIgG
General Information
| Short Description | Rabbit polyclonal ABCB8 (469-718) antibody for use in WB, IHC-P, IF, ICC and ELISA in human, mouse and rat samples. Datasheet included with dilution recommendations, and related reagents. |
| Applications | WB/IHC-P/IF/ICC/ELISA |
| Host | Rabbit |
| Reactivity | Human/Mouse/Rat |
| Note | STRICTLY FOR FURTHER SCIENTIFIC RESEARCH USE ONLY (RUO). MUST NOT TO BE USED IN DIAGNOSTIC OR THERAPEUTIC APPLICATIONS. |
Product Properties
| Clonality | Polyclonal |
| Isotype | IgG |
| Conjugation | Unconjugated |
| Concentration | Lot specific |
| Purification | Affinity purification |
| Dilution Range | WB:1:500-1:2000IHC-P:1:50-1:100IF/ICC:1:50-1:100ELISA:Recommended starting concentration is 1 Mu g/mL. Please optimize the concentration based on your specific assay requirements. |
| Formulation | PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. |
| Storage Instruction | Store at-20°C for up to 1 year from the date of receipt, and avoid repeat freeze-thaw cycles. |
Target Information
| Gene Symbol | ABCB8 |
| Gene ID | 11194 |
| Uniprot ID | MITOS_HUMAN |
| Immunogen Region | 469-718 |
| Immunogen Sequence | GFEVLKDFTLTLPPGKIVAL VGQSGGGKTTVASLLERFYD PTAGVVMLDGRDLRTLDPSW LRGQVVGFISQEPVLFGTTI MENIRFGKLEASDEEVYTAA REANAHEFITSFPEGYNTVV GERGTTLSGGQKQRLAIARA LIKQPTVLILDEATSALDAE SERVVQEALDRASAGRTVLV IAHRLSTVRGAHCIVVMADG RVWEAGTHEELLKKGGLYAE LIRRQALDAPRTAAPPPKK |
| Specificity | Recombinant fusion protein containing a sequence corresponding to amino acids 469-718 of human ABCB8 (NP_009119.2). |
Additional Info
| Tissue Specificity | Ubiquitous. |
| Function | ATP-binding subunit of the mitochondrial ATP-gated potassium channel (mitoK(ATP)). Together with pore-forming subunit CCDC51/MITOK of the mitoK(ATP) channel, mediates ATP-dependent potassium currents across the mitochondrial inner membrane. An increase in ATP intracellular levels closes the channel, inhibiting K(+) transport, whereas a decrease in ATP levels enhances K(+) uptake in the mitochondrial matrix. Plays a role in mitochondrial iron transport. Required for maintenance of normal cardiac function, possibly by influencing mitochondrial iron export and regulating the maturation of cytosolic iron sulfur cluster-containing enzymes. |
| Protein Name | Mitochondrial Potassium Channel Atp-Binding SubunitAtp-Binding Cassette Sub-Family B Member 8 - MitochondrialAbcb8Mitochondrial Atp-Binding Cassette 1M-Abc1Mitochondrial Sulfonylurea-ReceptorMitosur |
| Database Links | Reactome: R-HSA-1369007 |
| Cellular Localisation | Mitochondrion Inner MembraneMulti-Pass Membrane Protein |
| Alternative Antibody Names | Anti-Mitochondrial Potassium Channel Atp-Binding Subunit antibodyAnti-Atp-Binding Cassette Sub-Family B Member 8 - Mitochondrial antibodyAnti-Abcb8 antibodyAnti-Mitochondrial Atp-Binding Cassette 1 antibodyAnti-M-Abc1 antibodyAnti-Mitochondrial Sulfonylurea-Receptor antibodyAnti-Mitosur antibodyAnti-ABCB8 antibodyAnti-MABC1 antibodyAnti-MITOSUR antibody |
Information sourced from Uniprot.org